{"id":132749,"date":"2026-07-02T09:33:36","date_gmt":"2026-07-02T09:33:36","guid":{"rendered":"https:\/\/indogenmed.org\/resource\/tagrisso-top-trial-chemo-combination\/"},"modified":"2026-09-20T02:43:51","modified_gmt":"2026-09-20T02:43:51","slug":"tagrisso-top-trial-chemo-combination","status":"publish","type":"post","link":"https:\/\/indogenmed.org\/ja\/resource\/tagrisso-top-trial-chemo-combination\/","title":{"rendered":"\u30bf\u30b0\u30ea\u30c3\u30bd\uff08\u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6\uff09TOP\u8a66\u9a13\uff1a\u5316\u5b66\u7642\u6cd5\u3068\u306e\u4f75\u7528\u304c\u512a\u308c\u308b\u7406\u7531"},"content":{"rendered":"<p>\u9032\u884c<a href=\"https:\/\/indogenmed.org\/medicine\/lung-cancer\/\" target=\"_blank\" rel=\"noopener\">\u80ba\u304c\u3093<\/a>\u306e\u6cbb\u7642\u306f\u5927\u304d\u304f\u9032\u6b69\u3057\u307e\u3057\u305f\u3002\u9577\u5e74\u3001\u60a3\u8005\u3055\u3093\u304c\u983c\u308c\u308b\u306e\u306f\u5f93\u6765\u306e\u5316\u5b66\u7642\u6cd5\u3060\u3051\u3067\u3001\u304c\u3093\u7d30\u80de\u3092\u6392\u9664\u3059\u308b\u4e00\u65b9\u3001\u5168\u8eab\u306b\u3055\u307e\u3056\u307e\u306a\u526f\u4f5c\u7528\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u7cbe\u5bc6\u533b\u7642\u306e\u98db\u8e8d\u306b\u3088\u3063\u3066\u72b6\u6cc1\u306f\u5287\u7684\u306b\u5909\u308f\u308a\u307e\u3057\u305f\u3002\u80ba\u304c\u3093\u306e\u767a\u751f\u306b\u306f\u591a\u304f\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u753b\u4e00\u7684\u306a\u6cbb\u7642\u3067\u306f\u306a\u304f\u3001\u9320\u5264\u306b\u3088\u308b\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u304c\u5fc5\u8981\u306b\u306a\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n<p>\u30a2\u30b9\u30c8\u30e9\u30bc\u30cd\u30ab\u793e\u306e\u30bf\u30b0\u30ea\u30c3\u30bd\uff08\u4e00\u822c\u540d\uff1a<a href=\"https:\/\/indogenmed.org\/ja\/molecule\/osimertinib\/\" target=\"_blank\" rel=\"noopener\">\u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6<\/a>\uff09\u306f\u3001\u3053\u306e\u9769\u547d\u306e\u4e2d\u5fc3\u7684\u306a\u5b58\u5728\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u7b2c3\u4e16\u4ee3\u306e\u9320\u5264\u306f\u3001EGFR\u5909\u7570\u967d\u6027\u306e\u9032\u884c\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\uff08NSCLC\uff09\u306e\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u65b0\u305f\u306a\u6a19\u6e96\u6cbb\u7642\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u3057\u304b\u3057\u533b\u5b66\u306e\u9032\u6b69\u306f\u6b62\u307e\u308a\u307e\u305b\u3093\u3002\u30bf\u30b0\u30ea\u30c3\u30bd\u5358\u5264\u3067\u3059\u3067\u306b\u4f55\u5343\u4eba\u3082\u306e\u4eba\u304c\u6551\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u304c\u3093\u7d30\u80de\u306f\u6642\u9593\u3068\u3068\u3082\u306b\u3053\u306e\u6cbb\u7642\u3092\u3059\u308a\u629c\u3051\u308b\u65b9\u6cd5\u3092\u898b\u3064\u3051\u307e\u3059\u3002<\/p>\n<p> \u3053\u3046\u3057\u305f\u85ac\u5264\u8010\u6027\u3068\u95d8\u3046\u305f\u3081\u3001\u7814\u7a76\u8005\u305f\u3061\u306f\u753b\u671f\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u691c\u8a0e\u3057\u59cb\u3081\u307e\u3057\u305f\u3002<a href=\"https:\/\/indogenmed.org\/product\/tagrisso-80mg-tablets\/\" target=\"_blank\" rel=\"noopener\">\u30bf\u30b0\u30ea\u30c3\u30bd<\/a>\u306b\u3088\u308b\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u3068\u5316\u5b66\u7642\u6cd5\u3092\u3001\u6cbb\u7642\u306e\u6700\u521d\u304b\u3089\u7d44\u307f\u5408\u308f\u305b\u305f\u3089\u3069\u3046\u306a\u308b\u304b\u3001\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002<\/p>\n<p>\u6700\u8fd1\u767a\u8868\u3055\u308c\u305f2\u3064\u306e\u91cd\u8981\u306a\u81e8\u5e8a\u8a66\u9a13\u3001\u7b2cIII\u76f8FLAURA2\u8a66\u9a13\u3068\u7b2cIII\u76f8TOP\u8a66\u9a13\u306e\u7d50\u679c\u304c\u3001\u3053\u306e\u6cbb\u7642\u306e\u6709\u52b9\u6027\u3092\u88cf\u4ed8\u3051\u307e\u3057\u305f\u3002\u3053\u306e\u30ac\u30a4\u30c9\u3067\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n<h2>\u79d1\u5b66\u7684\u6839\u62e0\uff1a\u306a\u305c\u5206\u5b50\u6a19\u7684\u85ac\u3068\u5316\u5b66\u7642\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u306e\u304b\uff1f<\/h2>\n<p>\u3053\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u306a\u305c\u52b9\u679c\u7684\u306a\u306e\u304b\u3092\u7406\u89e3\u3059\u308b\u306b\u306f\u3001\u4f53\u5185\u3067\u304c\u3093\u7d30\u80de\u304c\u3069\u306e\u3088\u3046\u306b\u632f\u308b\u821e\u3046\u304b\u3092\u77e5\u308b\u3053\u3068\u304c\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n<h3>\u5358\u5264\u7642\u6cd5\u306e\u5f37\u307f\u3068\u9650\u754c<\/h3>\n<p>\u5358\u72ec\u3067\u6295\u4e0e\u3057\u305f\u5834\u5408\u3001\u3053\u306e\u85ac\u306fEGFR\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u85ac\uff08TKI\uff09\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002<\/p>\n<p>\u304c\u3093\u7d30\u80de\u4e0a\u306e\u5909\u7570\u3057\u305f\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\u3092\u30d6\u30ed\u30c3\u30af\u3057\u3001\u816b\u760d\u306b\u5206\u88c2\u3092\u6307\u793a\u3059\u308b\u7d30\u80de\u5185\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u6b62\u3081\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u6cbb\u7642\u306f\u591a\u304f\u306e\u4eba\u306b\u975e\u5e38\u306b\u3088\u304f\u52b9\u304d\u3001\u816b\u760d\u306f\u901f\u3084\u304b\u306b\u7e2e\u5c0f\u3057\u3001\u75c7\u72b6\u3082\u6539\u5584\u3057\u307e\u3059\u3002<\/p>\n<p>\u3057\u304b\u3057\u3001\u304c\u3093\u306e\u816b\u760d\u306f\u901a\u5e38\u5747\u4e00\u306a\u584a\u3067\u306f\u306a\u304f\u3001\u3055\u307e\u3056\u307e\u306a\u30af\u30ed\u30fc\u30f3\u7d30\u80de\u96c6\u56e3\u306e\u96c6\u307e\u308a\u3067\u3059\u3002<\/p>\n<p>\u6642\u9593\u304c\u305f\u3064\u3068\u3001\u85ac\u304cEGFR\u5909\u7570\u3092\u6301\u3064\u4e3b\u8981\u306a\u304c\u3093\u7d30\u80de\u3092\u6b7b\u6ec5\u3055\u305b\u3066\u3082\u3001\u4e00\u90e8\u306e\u304c\u3093\u7d30\u80de\u306f\u751f\u304d\u5ef6\u3073\u3066\u5897\u6b96\u3059\u308b\u5225\u306e\u624b\u6bb5\u3092\u7372\u5f97\u3057\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u7d30\u80de\u304c\u5897\u6b96\u3057\u3066\u85ac\u306b\u8010\u6027\u3092\u6301\u3064\u3088\u3046\u306b\u306a\u308a\u3001\u85ac\u304c\u52b9\u304b\u306a\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<h3>\u4e8c\u91cd\u306e\u653b\u6483\u52b9\u679c<br \/>\n<\/h3>\n<p>\u901a\u5e38\u30da\u30e1\u30c8\u30ec\u30ad\u30bb\u30c9\u3068\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u307e\u305f\u306f\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u30d7\u30e9\u30c1\u30ca\u88fd\u5264\u30d9\u30fc\u30b9\u306e\u5316\u5b66\u7642\u6cd5\u3092\u3001\u6bce\u65e5\u306e\u30bf\u30b0\u30ea\u30c3\u30bd\u3068\u4f75\u7528\u3057\u3066\u3001\u304c\u3093\u306b\u4e8c\u65b9\u5411\u304b\u3089\u653b\u6483\u3092\u4ed5\u639b\u3051\u307e\u3059\u3002<\/p>\n<ol>\n<li aria-level=\"1\">\u6a19\u7684\u653b\u6483\uff1a\u30bf\u30b0\u30ea\u30c3\u30bd\u304cEGFR\u306e\u4e3b\u8981\u306a\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u3092\u7d99\u7d9a\u7684\u306b\u30d6\u30ed\u30c3\u30af\u3057\u3001\u816b\u760d\u306e\u5927\u90e8\u5206\u3092\u6291\u3048\u8fbc\u307f\u307e\u3059\u3002<\/li>\n<li aria-level=\"1\">\u5e83\u7bc4\u56f2\u306e\u653b\u6483\uff1a\u5316\u5b66\u7642\u6cd5\u304c\u901f\u304f\u5206\u88c2\u3059\u308b\u7d30\u80de\u3092\u7a4d\u6975\u7684\u306b\u7834\u58ca\u3057\u3001\u96a0\u308c\u305f\u30fb\u653b\u6483\u7684\u306a\u30fb\u5909\u7570\u3057\u305f\u7d30\u80de\u306e\u30af\u30ed\u30fc\u30f3\u304c\u9069\u5fdc\u3057\u3066TKI\u306b\u8010\u6027\u3092\u6301\u3064\u524d\u306b\u4e00\u6383\u3057\u307e\u3059\u3002<\/li>\n<\/ol>\n<p>\u3053\u306e\u5f37\u529b\u306a\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\u3001\u816b\u760d\u304c\u306f\u3063\u304d\u308a\u3068\u3057\u305f\u8010\u6027\u7d4c\u8def\u3092\u78ba\u7acb\u3059\u308b\u306e\u3092\u9632\u304e\u3001\u9320\u5264\u5358\u72ec\u3088\u308a\u3082\u306f\u308b\u304b\u306b\u9577\u304f\u304c\u3093\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u307e\u3059\u3002<\/p>\n<h2>\u753b\u671f\u7684\u306a\u30c7\u30fc\u30bf\uff1aFLAURA2\u304c\u751f\u5b58\u671f\u9593\u306e\u65b0\u305f\u306a\u57fa\u6e96\u3092\u78ba\u7acb<br 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\/>\n<\/h3>\n<p>\u8a66\u9a13\u306e\u7d50\u679c\u3001\u4f75\u7528\u7642\u6cd5\u306e\u5168\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u7d044\u5e74\uff08\u6b63\u78ba\u306b\u306f47.5\u304b\u6708\uff09\u3067\u3057\u305f\u3002<\/p>\n<p>\u4e00\u65b9\u3001\u30bf\u30b0\u30ea\u30c3\u30bd\u5358\u72ec\u306e\u60a3\u8005\u3055\u3093\u306e\u5168\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f37.6\u304b\u6708\u3067\u3057\u305f\u3002<\/p>\n<p>\u5168\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u304c\u3055\u3089\u306b10\u304b\u6708\u5ef6\u3073\u305f\u3053\u3068\u306f\u3001\u73fe\u4ee3\u306e\u816b\u760d\u5b66\u306b\u3068\u3063\u3066\u5927\u304d\u306a\u524d\u9032\u3067\u3059\u3002<\/p>\n<p>\u3055\u3089\u306b\u8a66\u9a13\u7d50\u679c\u306b\u3088\u308b\u3068\u3001\u6cbb\u7642\u958b\u59cb\u6642\u304b\u3089\u4f75\u7528\u7642\u6cd5\u3092\u53d7\u3051\u305f\u60a3\u8005\u3055\u3093\u3067\u306f\u3001\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c23\uff05\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.77\uff09\u3002<\/p>\n<h2>TOP\u8a66\u9a13\uff1a\u9ad8\u30ea\u30b9\u30af\u306eTP53\u5909\u7570\u306b\u5bfe\u3059\u308b\u5e0c\u671b<br \/>\n<\/h2>\n<p>FLAURA2\u8a66\u9a13\u304c\u9032\u884c\u80ba\u304c\u3093\u306e\u60a3\u8005\u3055\u3093\u5168\u822c\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u305f\u306e\u306b\u5bfe\u3057\u3001\u7b2cIII\u76f8TOP\u8a66\u9a13\u306f\u7279\u306b\u5f31\u3044\u7acb\u5834\u306b\u3042\u308b\u7279\u5b9a\u306e\u60a3\u8005\u3055\u3093\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u7126\u70b9\u3092\u5f53\u3066\u307e\u3057\u305f\u3002<\/p>\n<h3>\u300c\u4e8c\u91cd\u5909\u7570\u300d\u306e\u554f\u984c<br \/>\n<\/h3>\n<p>\u80ba\u304c\u3093\u306e\u691c\u4f53\u3092\u691c\u67fb\u3059\u308b\u969b\u3001\u533b\u5e2b\u306f\u307e\u305a\u4e3b\u8981\u306a\u5909\u7570\u3092\u8abf\u3079\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u3046\u3057\u305f\u60a3\u8005\u3055\u3093\u306e\u6700\u592760\uff05\u306fTP53\u5909\u7570\u3068\u547c\u3070\u308c\u308b2\u3064\u76ee\u306e\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>TP53\u907a\u4f1d\u5b50\u306f\u3001\u304c\u3093\u6291\u5236\u306e\u4ed5\u7d44\u307f\u3068\u3057\u3066\u50cd\u304d\u3001\u7d30\u80de\u306eDNA\u640d\u50b7\u306e\u4fee\u5fa9\u3082\u52a9\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>TP53\u907a\u4f1d\u5b50\u304c\u6b20\u9665\u3092\u6301\u3063\u305f\u308a\u50cd\u304b\u306a\u304f\u306a\u3063\u305f\u308a\u3059\u308b\u3068\u3001\u4f53\u306b\u672c\u6765\u5099\u308f\u3063\u305f\u9632\u5fa1\u6a5f\u69cb\u304c\u5931\u308f\u308c\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u5909\u7570\u3092\u4f75\u305b\u6301\u3064\u60a3\u8005\u3055\u3093\u306f\u3001\u751f\u7269\u5b66\u7684\u306b\u9ad8\u30ea\u30b9\u30af\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306a\u60a3\u8005\u3055\u3093\u306e\u816b\u760d\u306f\u3001\u3053\u308c\u307e\u3067\u653b\u6483\u6027\u304c\u9ad8\u304f\u3001\u5f93\u6765\u306e\u6cbb\u7642\u304c\u52b9\u304d\u306b\u304f\u304f\u3001TKI\u9320\u5264\u5358\u72ec\u3067\u6cbb\u7642\u3059\u308b\u3068\u901f\u3084\u304b\u306b\u518d\u5897\u6b96\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n<h3>TOP\u8a66\u9a13\u306e\u753b\u671f\u7684\u306a\u6210\u679c<br \/>\n<\/h3>\n<p>TOP\u8a66\u9a13\u306f\u3001\u3053\u3046\u3057\u305f\u653b\u6483\u7684\u306a\u4e8c\u91cd\u5909\u7570\u306b\u5bfe\u3059\u308b\u30bf\u30b0\u30ea\u30c3\u30bd\u3068\u5316\u5b66\u7642\u6cd5\u306e\u4f75\u7528\u306e\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u5316\u5b66\u7642\u6cd5\u3092\u52a0\u3048\u308b\u3053\u3068\u3067\u3001\u3053\u308c\u3089\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u3055\u3093\u306e\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u304c2\u500d\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u3068\u306f\u3001\u304c\u3093\u304c\u5897\u5927\u30fb\u9032\u884c\u305b\u305a\u306b\u751f\u5b58\u3057\u3066\u3044\u308b\u671f\u9593\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\">TP53\u306e\u5909\u7570\u3092\u4f75\u305b\u6301\u3064\u60a3\u8005\u3055\u3093\u3067\u30bf\u30b0\u30ea\u30c3\u30bd\u5358\u72ec\u6cbb\u7642\u306e\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\uff1a15.6\u304b\u6708\u3002<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">TP53\u306e\u5909\u7570\u3092\u4f75\u305b\u6301\u3064\u60a3\u8005\u3055\u3093\u3067\u30bf\u30b0\u30ea\u30c3\u30bd\u3068\u5316\u5b66\u7642\u6cd5\u306e\u4f75\u7528\u306e\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\uff1a34.0\u304b\u6708\u3002<\/li>\n<\/ul>\n<p>\u304c\u3093\u304c\u9032\u884c\u3059\u308b\u307e\u3067\u306e\u671f\u9593\u3092\u7d043\u5e74\u306b\u5ef6\u3070\u3057\u305f\u3053\u3068\u3067\u3001\u4f75\u7528\u7642\u6cd5\u306fTP53\u5909\u7570\u306e\u653b\u6483\u6027\u3092\u52b9\u679c\u7684\u306b\u6291\u3048\u3089\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u3001\u3053\u308c\u307e\u3067\u3088\u308a\u53b3\u3057\u3044\u4e88\u5f8c\u306b\u76f4\u9762\u3057\u3066\u3044\u305f\u60a3\u8005\u3055\u3093\u306b\u91cd\u8981\u306a\u5e0c\u671b\u3092\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u3002<\/p>\n<h2>\u6bd4\u8f03\u8868<br \/>\n<\/h2>\n<p>2\u3064\u306e\u6cbb\u7642\u6cd5\u306e\u9055\u3044\u3092\u308f\u304b\u308a\u3084\u3059\u304f\u3059\u308b\u305f\u3081\u3001\u6b21\u306e\u8868\u3067\u4e21\u65b9\u306e\u81e8\u5e8a\u8a66\u9a13\u30c7\u30fc\u30bf\u3092\u6bd4\u8f03\u3057\u307e\u3059\u3002<\/p>\n<table style=\"height: 397px;\" width=\"1415\">\n<tbody>\n<tr>\n<td>\n<p>\u81e8\u5e8a\u7684\u7279\u5fb4<\/p>\n<\/td>\n<td>\n<p>\u30bf\u30b0\u30ea\u30c3\u30bd\u5358\u5264\u7642\u6cd5\uff08\u9320\u5264\u306e\u307f\uff09<\/p>\n<\/td>\n<td>\n<p>\u30bf\u30b0\u30ea\u30c3\u30bd\uff0b\u5316\u5b66\u7642\u6cd5\u306e\u4f75\u7528<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p>\u4e3b\u306a\u6cbb\u7642\u76ee\u6a19<\/p>\n<\/td>\n<td>\n<p>\u9577\u671f\u7684\u306a\u6a19\u7684\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/p>\n<\/td>\n<td>\n<p>\u6700\u521d\u304b\u3089\u5f37\u5316\u3057\u3066\u85ac\u5264\u8010\u6027\u3092\u9632\u3050<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p>\u5168\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\uff08FLAURA2\uff09<\/p>\n<\/td>\n<td>\n<p>37.6\u304b\u6708<\/p>\n<\/td>\n<td>\n<p>\u7d044\u5e74\uff0847.5\u304b\u6708\uff09<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p>TP53\u5909\u7570\u4f75\u5b58\u4f8b\u306e\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\uff08TOP\u8a66\u9a13\uff09<\/p>\n<\/td>\n<td>\n<p>15.6\u304b\u6708<\/p>\n<\/td>\n<td>\n<p>34.0\u304b\u6708\uff08\u671f\u9593\u304c2\u500d\uff09<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p>\u6cbb\u7642\u306e\u65b9\u6cd5<\/p>\n<\/td>\n<td>\n<p>\u81ea\u5b85\u30671\u65e51\u56de\u306e\u7d4c\u53e3\u9320<\/p>\n<\/td>\n<td>\n<p>\u6bce\u65e5\u306e\u7d4c\u53e3\u9320\uff0b\u70b9\u6ef4\u5316\u5b66\u7642\u6cd54\u30b5\u30a4\u30af\u30eb\u3001\u305d\u306e\u5f8c\u7dad\u6301\u5316\u5b66\u7642\u6cd5\u306e\u70b9\u6ef4<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p>\u4e3b\u306a\u526f\u4f5c\u7528<\/p>\n<\/td>\n<td>\n<p>\u4e00\u822c\u306b\u8efd\u5ea6\uff08\u76ae\u75b9\u3001\u4e0b\u75e2\u3001\u76ae\u819a\u306e\u4e7e\u71e5\uff09<\/p>\n<\/td>\n<td>\n<p>\u4e2d\u7b49\u5ea6\u301c\u91cd\u5ea6\uff08\u75b2\u52b4\u3001\u5410\u304d\u6c17\u3001\u8840\u7403\u6570\u306e\u6e1b\u5c11\uff09<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>FDA\u627f\u8a8d\uff1a\u3053\u306e\u4f75\u7528\u7642\u6cd5\u3067\u6700\u3082\u6069\u6075\u3092\u53d7\u3051\u308b\u306e\u306f\uff1f<br \/>\n<\/h2>\n<p>\u3053\u306e\u81e8\u5e8a\u8a66\u9a13\u306e\u6210\u529f\u3092\u53d7\u3051\u3066\u3001\u5bfe\u5fdc\u306f\u8fc5\u901f\u3067\u3057\u305f\u3002FDA\u306f\u3001EGFR\u5909\u7570\u967d\u6027\u306e\u5c40\u6240\u9032\u884c\u307e\u305f\u306f\u8ee2\u79fb\u6027NSCLC\u306e\u4e00\u6b21\u6cbb\u7642\u3068\u3057\u3066\u3001\u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6\u3068\u5316\u5b66\u7642\u6cd5\u306e\u4f75\u7528\u3092\u6b63\u5f0f\u306b\u627f\u8a8d\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u6cbb\u7642\u306f\u5e83\u304f\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8a73\u7d30\u306a\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u304b\u3089\u3001\u4e00\u90e8\u306e\u60a3\u8005\u3055\u3093\u304c\u7279\u306b\u5927\u304d\u306a\u6069\u6075\u3092\u53d7\u3051\u3089\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<ol>\n<li> \u4e2d\u67a2\u795e\u7d4c\u7cfb\uff08CNS\uff09\u8ee2\u79fb\u306e\u3042\u308b\u60a3\u8005\u3055\u3093<\/li>\n<\/ol>\n<p>\u8133\u8ee2\u79fb\u306f\u9032\u884c\u80ba\u304c\u3093\u3067\u3088\u304f\u307f\u3089\u308c\u307e\u3059\u3002\u591a\u304f\u306e\u85ac\u304c\u8840\u6db2\u8133\u95a2\u9580\u3092\u901a\u904e\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u8133\u8ee2\u79fb\u306e\u6cbb\u7642\u306f\u305a\u3063\u3068\u96e3\u3057\u3044\u3082\u306e\u3067\u3057\u305f\u3002\u30bf\u30b0\u30ea\u30c3\u30bd\u306f\u8840\u6db2\u8133\u95a2\u9580\u3092\u52b9\u679c\u7684\u306b\u901a\u904e\u3057\u307e\u3059\u304c\u3001\u5316\u5b66\u7642\u6cd5\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u8133\u816b\u760d\u3092\u3055\u3089\u306b\u52b9\u679c\u7684\u306b\u6291\u3048\u307e\u3057\u305f\u3002<\/p>\n<ol start=\"2\">\n<li> \u30a8\u30af\u30bd\u30f321\u306eL858R\u7f6e\u63db\u5909\u7570\u306e\u3042\u308b\u60a3\u8005\u3055\u3093<\/li>\n<\/ol>\n<p>EGFR\u5909\u7570\u306f\u3001\u30a8\u30af\u30bd\u30f319\u6b20\u5931\u3068\u30a8\u30af\u30bd\u30f321\u306eL858R\u5909\u7570\u3068\u3044\u30462\u3064\u306e\u4e3b\u306a\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u3051\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u4e00\u822c\u306b\u3001\u30a8\u30af\u30bd\u30f321\u5909\u7570\u306e\u816b\u760d\u306f\u30a8\u30af\u30bd\u30f319\u5909\u7570\u306e\u816b\u760d\u3088\u308a\u3082TKI\u9320\u5264\u5358\u72ec\u3067\u306e\u6cbb\u7642\u53cd\u5fdc\u304c\u52a3\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>FLAURA2\u8a66\u9a13\u3067\u306f\u3001\u5316\u5b66\u7642\u6cd5\u3092\u52a0\u3048\u308b\u3053\u3068\u3067\u3053\u306e\u5f31\u70b9\u3092\u514b\u670d\u3067\u304d\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h2>\u526f\u4f5c\u7528\uff1a\u52b9\u679c\u3068\u751f\u6d3b\u306e\u8cea\u306e\u30d0\u30e9\u30f3\u30b9<br \/>\n<\/h2>\n<p>\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u6bd4\u8f03<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\">\u30bf\u30b0\u30ea\u30c3\u30bd\u5358\u5264\u7642\u6cd5\uff1a\u9320\u5264\u306e\u307f\u306e\u6cbb\u7642\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u975e\u5e38\u306b\u5fcd\u5bb9\u6027\u304c\u9ad8\u3044\u3082\u306e\u3067\u3059\u3002\u6700\u3082\u3088\u304f\u3042\u308b\u526f\u4f5c\u7528\u306f\u8efd\u3044\u76ae\u75b9\u3001\u722a\u304c\u3082\u308d\u304f\u306a\u308b\u3053\u3068\u3001\u8efd\u3044\u4e0b\u75e2\u3001\u75b2\u52b4\u3067\u3001\u65e5\u5e38\u751f\u6d3b\u3078\u306e\u5f71\u97ff\u306f\u3054\u304f\u308f\u305a\u304b\u3067\u3059\u3002<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">\u30bf\u30b0\u30ea\u30c3\u30bd\u3068\u5316\u5b66\u7642\u6cd5\u306e\u4f75\u7528\uff1a\u5316\u5b66\u7642\u6cd5\u306b\u3088\u308b\u7d30\u80de\u6bd2\u6027\u306e\u526f\u4f5c\u7528\u304c\u52a0\u308f\u308a\u307e\u3059\u3002\u75b2\u52b4\u306e\u5897\u52a0\u3001\u5410\u304d\u6c17\u3001\u8131\u6bdb\uff08\u9aea\u304c\u8584\u304f\u306a\u308b\uff09\u3001\u4e00\u6642\u7684\u306a\u8840\u6db2\u6bd2\u6027\u306a\u3069\u3067\u3059\u3002\u5316\u5b66\u7642\u6cd5\u306f\u4e00\u6642\u7684\u306b\u9aa8\u9ac4\u306e\u50cd\u304d\u3092\u59a8\u3052\u3001\u8ca7\u8840\uff08\u8d64\u8840\u7403\u306e\u6e1b\u5c11\u306b\u3088\u308b\u75b2\u308c\uff09\u3084\u597d\u4e2d\u7403\u6e1b\u5c11\uff08\u767d\u8840\u7403\u304c\u6e1b\u308a\u611f\u67d3\u3057\u3084\u3059\u304f\u306a\u308b\uff09\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<h3>\u652f\u6301\u7642\u6cd5\u3067\u6cbb\u7642\u3092\u4e57\u308a\u5207\u308b<br \/>\n<\/h3>\n<p>\u5316\u5b66\u7642\u6cd5\u306f\u6cbb\u7642\u306e\u4e00\u6642\u7684\u306a\u6bb5\u968e\u3067\u3042\u308b\u3053\u3068\u3092\u7406\u89e3\u3057\u3066\u304a\u304f\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002\u901a\u5e38\u3001\u5f37\u529b\u306a\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u308b\u306e\u306f4\u30b3\u30fc\u30b9\uff08\u7d043\u9031\u9593\u9593\u9694\uff09\u3060\u3051\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u6bb5\u968e\u304c\u7d42\u308f\u308b\u3068\u7dad\u6301\u7642\u6cd5\u306b\u79fb\u308a\u3001\u6bd2\u6027\u306f\u5927\u5e45\u306b\u8efd\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u816b\u760d\u5185\u79d1\u533b\u306f\u526f\u4f5c\u7528\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u305f\u3081\u3001\u5316\u5b66\u7642\u6cd5\u524d\u306e\u5f37\u529b\u306a\u5236\u5410\u85ac\u3084\u3001\u30da\u30b0\u30d5\u30a3\u30eb\u30b0\u30e9\u30b9\u30c1\u30e0\u306a\u3069\u306e\u6210\u9577\u56e0\u5b50\u306e\u6ce8\u5c04\u3068\u3044\u3063\u305f\u652f\u6301\u7642\u6cd5\u3092\u7a4d\u6975\u7684\u306b\u884c\u3044\u307e\u3059\u3002<\/p>\n<h2>\u307e\u3068\u3081\uff1a\u4e00\u7dd2\u306b\u6c7a\u3081\u308b\u6cbb\u7642\u65b9\u91dd<br \/>\n<\/h2>\n<p>FLAURA2\u8a66\u9a13\u3068TOP\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001\u533b\u7642\u754c\u306e\u9032\u884c\u80ba\u304c\u3093\u3078\u306e\u53d6\u308a\u7d44\u307f\u65b9\u3092\u5287\u7684\u306b\u5909\u3048\u307e\u3057\u305f\u3002<\/p>\n<p>\u4eca\u3067\u306f\u3001\u30bf\u30b0\u30ea\u30c3\u30bd\u3068\u5316\u5b66\u7642\u6cd5\u306e\u4f75\u7528\u306b\u3088\u3063\u3066\u5168\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u304c\u7d044\u5e74\uff0847.5\u304b\u6708\uff09\u306b\u5ef6\u3073\u3001TP53\u5909\u7570\u3092\u4f75\u305b\u6301\u3064\u60a3\u8005\u3055\u3093\u3067\u306f\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u304c2\u500d\uff0815.6\u304b\u6708\u306b\u5bfe\u305734.0\u304b\u6708\uff09\u306b\u306a\u308b\u3053\u3068\u304c\u78ba\u5b9f\u306b\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u5358\u5264\u304b\u4f75\u7528\u7642\u6cd5\u304b\u306e\u9078\u629e\u306f\u3001\u816b\u760d\u5185\u79d1\u533b\u3068\u30aa\u30fc\u30d7\u30f3\u306b\u8a71\u3057\u5408\u3063\u3066\u6c7a\u3081\u308b\u3079\u304d\u3067\u3059\u3002<\/p>\n<p>\u4f53\u529b\u304c\u3042\u308a\u3001\u816b\u760d\u3092\u9577\u671f\u9593\u6291\u3048\u308b\u3053\u3068\u3092\u91cd\u8996\u3059\u308b\u306a\u3089\u3001\u6700\u521d\u304b\u3089\u306e\u4f75\u7528\u7642\u6cd5\u304c\u826f\u3044\u9078\u629e\u3067\u3059\u3002<\/p>\n<p>\u4f53\u304c\u5f31\u3063\u3066\u3044\u308b\u5834\u5408\u3084\u3001\u3088\u308a\u7a4f\u3084\u304b\u306a\u65e5\u5e38\u3092\u671b\u3080\u5834\u5408\u306f\u3001\u30bf\u30b0\u30ea\u30c3\u30bd\u5358\u5264\u304b\u3089\u59cb\u3081\u308b\u306e\u304c\u826f\u3044\u9078\u629e\u3067\u3059\u3002<\/p>\n<h2>FAQ<\/h2>\n<h3>1. \u30bf\u30b0\u30ea\u30c3\u30bd\u5358\u5264\u3067\u59cb\u3081\u3066\u3001\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u3063\u305f\u3089\u5f8c\u304b\u3089\u5316\u5b66\u7642\u6cd5\u3092\u8ffd\u52a0\u3067\u304d\u308b\uff1f<br \/>\n<\/h3>\n<p>\u4e8c\u6b21\u6cbb\u7642\u3068\u3057\u3066\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u308b\u3053\u3068\u306f\u3044\u3064\u3067\u3082\u53ef\u80fd\u3067\u3059\u304c\u3001FLAURA2\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001\u6700\u521d\u304b\u3089\u4f75\u7528\u3059\u308b\u65b9\u304c\u306f\u308b\u304b\u306b\u6709\u76ca\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u78ba\u306b\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>2. TOP\u8a66\u9a13\u3067\u8a00\u53ca\u3055\u308c\u305f\u9ad8\u30ea\u30b9\u30af\u306eTP53\u5909\u7570\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u306f\u3069\u3046\u3059\u308c\u3070\u308f\u304b\u308b\uff1f<br \/>\n<\/h3>\n<p>\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08NGS\uff09\u306b\u3088\u308b\u5305\u62ec\u7684\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u691c\u67fb\u306e\u7d50\u679c\u3067\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u306f\u521d\u56de\u8a3a\u65ad\u6642\u306b\u8840\u6db2\u3084\u7d44\u7e54\u306e\u691c\u4f53\u3067\u884c\u3046\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u3059\u3002\u81ea\u5206\u306b\u898b\u3064\u304b\u3063\u305f\u4f75\u5b58\u5909\u7570\u306b\u3064\u3044\u3066\u3001\u9060\u616e\u306a\u304f\u533b\u5e2b\u306b\u8aac\u660e\u3092\u6c42\u3081\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<h3>3. \u4f75\u7528\u6cbb\u7642\u4e2d\u306b\u9aea\u306f\u3059\u3079\u3066\u629c\u3051\u308b\uff1f<br \/>\n<\/h3>\n<p>\u30da\u30e1\u30c8\u30ec\u30ad\u30bb\u30c9\u3084\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u306a\u3069\u306e\u6297\u304c\u3093\u5264\u3067\u9aea\u304c\u8584\u304f\u306a\u3063\u305f\u308a\u629c\u3051\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u4e73\u304c\u3093\u3084\u5375\u5de3\u304c\u3093\u306e\u5f37\u529b\u306a\u6cbb\u7642\u3067\u307f\u3089\u308c\u308b\u3088\u3046\u306a\u5b8c\u5168\u306a\u8131\u6bdb\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u5316\u5b66\u7642\u6cd5\u306e\u6700\u521d\u306e4\u30b5\u30a4\u30af\u30eb\u304c\u7d42\u308f\u308c\u3070\u3001\u9aea\u306f\u5143\u3069\u304a\u308a\u306b\u751f\u3048\u3066\u304d\u307e\u3059\u3002<\/p>\n<h2>\u53c2\u8003\u6587\u732e <\/h2>\n<ul>\n<li aria-level=\"1\">\u30a2\u30b9\u30c8\u30e9\u30bc\u30cd\u30ab\u30fb\u30e1\u30c7\u30a3\u30a2\u30bb\u30f3\u30bf\u30fc:<a href=\"https:\/\/www.astrazeneca.com\/media-centre\/press-releases\/2025\/tagrisso-plus-chemotherapy-demonstrated-a-median-overall-survival-of-nearly-four-years.html\" target=\"_blank\" rel=\"noopener nofollow\"> \u30bf\u30b0\u30ea\u30c3\u30bd\u3068\u5316\u5b66\u7642\u6cd5\u306e\u4f75\u7528\u3067\u5168\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u304c\u7d044\u5e74\u306b<\/a><\/li>\n<li aria-level=\"1\">The New England Journal of Medicine\uff08NEJM\uff09:<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2304594\" target=\"_blank\" rel=\"noopener nofollow\"> EGFR\u5909\u7570\u967d\u6027\u9032\u884cNSCLC\u306b\u304a\u3051\u308b\u5316\u5b66\u7642\u6cd5\u4f75\u7528\u307e\u305f\u306f\u975e\u4f75\u7528\u306e\u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6\uff08FLAURA2\uff09<\/a><\/li>\n<li aria-level=\"1\">\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09:<a href=\"https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-approves-osimertinib-chemotherapy-egfr-mutated-non-small-cell-lung-cancer\" target=\"_blank\" rel=\"noopener nofollow\"> FDA\u304cEGFR\u5909\u7570\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u306b\u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6\u3068\u5316\u5b66\u7642\u6cd5\u306e\u4f75\u7528\u3092\u627f\u8a8d<\/a><\/li>\n<li aria-level=\"1\">Oncology News Central\uff0fOncLive:<a href=\"https:\/\/www.onclive.com\/view\/osimertinib-plus-chemotherapy-doubles-pfs-in-egfr--tp53-mutant-advanced-nsclc\" rel=\"nofollow noopener\" target=\"_blank\"> TOP\u8a66\u9a13\u306e\u89e3\u6790\uff1a\u9ad8\u30ea\u30b9\u30afEGFR\/TP53\u5909\u7570\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3067\u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6\u3068\u5316\u5b66\u7642\u6cd5\u306e\u4f75\u7528\u304c\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u30922\u500d\u306b<\/a><\/li>\n<li aria-level=\"1\">NCBI Bookshelf:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK596656\/\" target=\"_blank\" rel=\"noopener nofollow\"> \u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3068\u7cbe\u5bc6\u816b\u760d\u5b66\u3067\u306e\u5fdc\u7528<\/a><\/li>\n<\/ul>\n<h2>\u95a2\u9023\u8a18\u4e8b\u3068\u8cc7\u6599<br \/>\n<\/h2>\n<p><em>\u3053\u306e\u85ac\u306e\u4ed5\u7d44\u307f\u3001\u8cbb\u7528\u9762\u306e\u9078\u629e\u80a2\u3001\u65e5\u3005\u306e\u30b1\u30a2\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308a\u305f\u3044\u65b9\u306f\u3001\u4ee5\u4e0b\u306e\u60a3\u8005\u5411\u3051\u30ac\u30a4\u30c9\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/em><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><em><b>\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u306e\u30bf\u30b0\u30ea\u30c3\u30bd\uff08\u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6\uff09\u306e\u80ba\u304c\u3093\u3078\u306e\u4f5c\u7528<\/b><b><br \/><\/b>\u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6\u304c\u3069\u306e\u3088\u3046\u306b\u816b\u760d\u7d30\u80de\u3092\u6a19\u7684\u306b\u3057\u3001\u5897\u6b96\u3092\u6b62\u3081\u308b\u306e\u304b\u3001\u305d\u306e\u79d1\u5b66\u3092\u89e3\u8aac\u3057\u307e\u3059\u3002<\/em><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><em><a href=\"https:\/\/indogenmed.org\/ja\/resource\/why-tagrisso-expensive-generic-alternatives-tagrisso\/\"><b>\u30bf\u30b0\u30ea\u30c3\u30bd\u306f\u306a\u305c\u9ad8\u3044\uff1f\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u306e\u4ee3\u66ff\u85ac\u306b\u3064\u3044\u3066<\/b><b><br \/><\/b><\/a>\u304c\u3093\u6cbb\u7642\u85ac\u306e\u4fa1\u683c\u3001\u6d77\u5916\u3067\u306e\u4fdd\u967a\u306e\u4f7f\u3044\u65b9\u3001\u624b\u9803\u3067\u8cea\u306e\u9ad8\u3044\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u306b\u5b89\u5168\u306b\u30a2\u30af\u30bb\u30b9\u3059\u308b\u65b9\u6cd5\u3092\u308f\u304b\u308a\u3084\u3059\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/em><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><em><a href=\"https:\/\/indogenmed.org\/ja\/resource\/osimertinib-first-line-therapy-approvals-for-lung-cancer\/\"><b>\u4e00\u6b21\u6cbb\u7642\u3068\u3057\u3066\u306e\u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6\uff1a\u4e3b\u306a\u627f\u8a8d\u3068\u80ba\u304c\u3093\u60a3\u8005\u3055\u3093\u3078\u306e\u30e1\u30ea\u30c3\u30c8<\/b><b><br \/><\/b><\/a>\u4e16\u754c\u306e\u898f\u5236\u5f53\u5c40\u304c\u3053\u306e\u85ac\u3092EGFR\u5909\u7570\u967d\u6027\u816b\u760d\u306e\u6700\u521d\u306e\u6a19\u6e96\u6cbb\u7642\u306b\u4f4d\u7f6e\u3065\u3051\u305f\u7406\u7531\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/em><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><em><a href=\"https:\/\/indogenmed.org\/ja\/resource\/osimertinib-side-effects-common-long-term-risks\/\"><b>\u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6\u306e\u526f\u4f5c\u7528\uff1a\u3088\u304f\u3042\u308b\u3082\u306e\u3001\u91cd\u3044\u3082\u306e\u3001\u9577\u671f\u7684\u306a\u30ea\u30b9\u30af<\/b><b><br 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