\u30a4\u30ec\u30c3\u30b5250mg\u9320\u306e\u7d39\u4ecb \u30a4\u30ec\u30c3\u30b5250mg\u9320\u306f\u3001\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\uff08NSCLC\uff09\u3068\u547c\u3070\u308c\u308b\u80ba\u304c\u3093\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u308b\u85ac\u3067\u3059\u3002\u3053\u306e\u85ac\u306f\u3001\u304c\u3093\u304c\u8ee2\u79fb\u3057\u3066\u3044\u308b\u3001\u307e\u305f\u306f\u624b\u8853\u3067\u6cbb\u7642\u3067\u304d\u306a\u3044\u4eba\u5411\u3051\u3067\u3059\u3002EGFR\uff08\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50\u306b\u7279\u5b9a\u306e\u5909\u5316\uff08\u5909\u7570\uff09\u304c\u3042\u308b\u60a3\u8005\u306b\u6700\u3082\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002\u30a4\u30ec\u30c3\u30b5\u306e\u6709\u52b9\u6210\u5206\u306f\u30b2\u30d5\u30a3\u30c1\u30cb\u30d6\u3067\u3001\u30a2\u30b9\u30c8\u30e9\u30bc\u30cd\u30ab\u793e\u304c\u88fd\u9020\u3057\u3066\u3044\u307e\u3059\u3002\u30a4\u30ec\u30c3\u30b5250mg\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u9045\u3089\u305b\u305f\u308a\u3001\u6b62\u3081\u305f\u308a\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u4f5c\u7528\u6a5f\u5e8f \u30a4\u30ec\u30c3\u30b5\u306f\u3001\u4f53\u5185\u306eEGFR\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u306b\u3059\u308b\u3053\u3068\u3067\u4f5c\u7528\u3057\u307e\u3059\u3002\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3068\u8ee2\u79fb\u3092\u52a9\u3051\u307e\u3059\u3002\u30a4\u30ec\u30c3\u30b5250mg\u306fEGFR\u3092\u963b\u5bb3\u3057\u3001\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u6b62\u3081\u3001\u816b\u760d\u3092\u7e2e\u5c0f\u3055\u305b\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u304c\u3093\u306e\u7ba1\u7406\u304c\u5bb9\u6613\u306b\u306a\u308a\u3001\u547c\u5438\u56f0\u96e3\u3084\u75b2\u52b4\u306a\u3069\u306e\u75c7\u72b6\u304c\u8efd\u6e1b\u3055\u308c\u307e\u3059\u3002\u30a4\u30ec\u30c3\u30b5250mg\u9320\u306e\u7528\u9014 \u30a4\u30ec\u30c3\u30b5250mg\u9320\u306f\u3001\u9032\u884c\u3057\u305f\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\uff08NSCLC\uff09\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u7279\u5b9a\u306e EGFR \u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u3092\u52a9\u3051\u307e\u3059\u3002\u4f53\u306e\u4ed6\u306e\u90e8\u5206\u306b\u8ee2\u79fb\u3057\u305f\u764c\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u307e\u3059\u3002\u533b\u5e2b\u306f\u3001NSCLC \u60a3\u8005\u306e\u7b2c\u4e00\u9078\u629e\u6cbb\u7642\u3068\u3057\u3066\u30a4\u30ec\u30c3\u30b5 \u30b2\u30d5\u30a3\u30c1\u30cb\u30d6 250mg \u3092\u3088\u304f\u4f7f\u7528\u3057\u307e\u3059\u3002\u7528\u91cf: \u901a\u5e38\u306e\u7528\u91cf: 1 \u65e5 1 \u9320 (250mg) \u3092\u670d\u7528\u3057\u307e\u3059\u3002\u670d\u7528\u65b9\u6cd5: \u9320\u5264\u3092\u6c34\u3067\u4e38\u3054\u3068\u98f2\u307f\u8fbc\u307f\u307e\u3059\u3002\u98df\u4e8b\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u670d\u7528\u3067\u304d\u307e\u3059\u3002\u670d\u7528\u3092\u5fd8\u308c\u305f\u5834\u5408: \u670d\u7528\u3092\u5fd8\u308c\u3066\u3001\u6b21\u306e\u670d\u7528\u4e88\u5b9a\u6642\u523b\u304c\u8fd1\u3044\u5834\u5408\u306f\u3001\u5fd8\u308c\u305f\u670d\u7528\u5206\u306f\u98db\u3070\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u5fd8\u308c\u305f\u670d\u7528\u5206\u3092\u88dc\u3046\u305f\u3081\u306b\u3001\u4e00\u5ea6\u306b 2 \u56de\u5206\u3092\u670d\u7528\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u30a4\u30ec\u30c3\u30b5 \u30b2\u30d5\u30a3\u30c1\u30cb\u30d6 250mg \u9320\u306e\u526f\u4f5c\u7528 \u3059\u3079\u3066\u306e\u533b\u85ac\u54c1\u3068\u540c\u69d8\u306b\u3001\u30a4\u30ec\u30c3\u30b5\u306b\u3082\u526f\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u8efd\u5ea6\u306a\u3082\u306e\u3082\u3042\u308c\u3070\u3001\u533b\u5e2b\u306e\u8a3a\u5bdf\u304c\u5fc5\u8981\u306a\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u4e00\u822c\u7684\u306a\u526f\u4f5c\u7528: \u4e0b\u75e2 \u767a\u75b9\u307e\u305f\u306f\u76ae\u819a\u306e\u4e7e\u71e5 \u5410\u304d\u6c17 \u98df\u6b32\u4e0d\u632f \u5026\u6020\u611f \u91cd\u7be4\u306a\u526f\u4f5c\u7528: \u91cd\u5ea6\u306e\u4e0b\u75e2\u307e\u305f\u306f\u8131\u6c34\u75c7\u72b6 \u75db\u307f\u3084\u304b\u3059\u307f\u76ee\u306a\u3069\u306e\u773c\u306e\u554f\u984c \u547c\u5438\u56f0\u96e3 \u809d\u81d3\u306e\u554f\u984c (\u76ae\u819a\u3084\u76ee\u306e\u9ec4\u5909\u3001\u6fc3\u3044\u5c3f) \u91cd\u7be4\u306a\u526f\u4f5c\u7528\u304c\u73fe\u308c\u305f\u5834\u5408\u306f\u3001\u3059\u3050\u306b\u533b\u5e2b\u306b\u4f1d\u3048\u3066\u304f\u3060\u3055\u3044\u3002 \u6ce8\u610f\u4e8b\u9805 \u30a4\u30ec\u30c3\u30b5\u3092\u670d\u7528\u3059\u308b\u524d\u306b\u3001\u533b\u5e2b\u306b\u5065\u5eb7\u72b6\u614b\u306b\u3064\u3044\u3066\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002 \u598a\u5a20\u4e2d\u307e\u305f\u306f\u6388\u4e73\u4e2d\u306e\u5834\u5408\u306f\u3001\u30a4\u30ec\u30c3\u30b5 240mg \u3092\u4f7f\u7528\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u8d64\u3061\u3083\u3093\u306b\u5bb3\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u809d\u81d3\u3001\u814e\u81d3\u3001\u307e\u305f\u306f\u80ba\u306b\u554f\u984c\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u533b\u5e2b\u306b\u77e5\u3089\u305b\u3066\u304f\u3060\u3055\u3044\u3002 \u533b\u5e2b\u306f\u3001\u809d\u81d3\u3092\u30c1\u30a7\u30c3\u30af\u3057\u3001\u7d4c\u904e\u3092\u76e3\u8996\u3059\u308b\u305f\u3081\u306b\u8840\u6db2\u691c\u67fb\u3092\u884c\u3046\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002 \u85ac\u7269\u76f8\u4e92\u4f5c\u7528 \u30a4\u30ec\u30c3\u30b5 \u30b2\u30d5\u30a3\u30c1\u30cb\u30d6 250 mg \u306f\u3001\u7279\u5b9a\u306e\u85ac\u3068\u3046\u307e\u304f\u6a5f\u80fd\u3057\u306a\u3044\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002 \u670d\u7528\u3057\u3066\u3044\u308b\u3059\u3079\u3066\u306e\u85ac\u3068\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3064\u3044\u3066\u533b\u5e2b\u306b\u4f1d\u3048\u3066\u304f\u3060\u3055\u3044\u3002 \u907f\u3051\u308b\u3079\u304d\u3082\u306e: \u30a4\u30ec\u30c3\u30b5\u670d\u7528\u5f8c 2 \u6642\u9593\u4ee5\u5185\u306b\u5236\u9178\u5264\u3092\u670d\u7528\u3059\u308b\u3053\u3068\u3002 \u4e00\u90e8\u306e\u6297\u751f\u7269\u8cea\u307e\u305f\u306f\u6297\u771f\u83cc\u85ac\u3002 \u30a4\u30ec\u30c3\u30b5\u3092\u670d\u7528\u4e2d\u306b\u65b0\u3057\u3044\u85ac\u3092\u958b\u59cb\u3059\u308b\u524d\u306b\u3001\u5fc5\u305a\u533b\u5e2b\u306b\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u8b66\u544a \u30a4\u30ec\u30c3\u30b5 \u30b2\u30d5\u30a3\u30c1\u30cb\u30d6 250mg \u9320\u3092\u670d\u7528\u3059\u308b\u524d\u306b\u3001\u533b\u7642\u5c02\u9580\u5bb6\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002 \u30bf\u30b0\u30ea\u30c3\u30bd vs \u30b2\u30d5\u30a3\u30c1\u30cb\u30d6 \u7279\u5fb4 \u30bf\u30b0\u30ea\u30c3\u30bd (\u30aa\u30b7\u30e1\u30eb\u30c1\u30cb\u30d6) \u30b2\u30d5\u30a3\u30c1\u30cb\u30d6 \u85ac\u52b9\u5206\u985e \u7b2c\u4e09\u4e16\u4ee3 EGFR \u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264 (TKI) \u7b2c\u4e00\u4e16\u4ee3 EGFR \u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264 (TKI) FDA \u627f\u8a8d 2015 \u5e74 2003 \u5e74 \u6a19\u7684\u5909\u7570 T790M \u8010\u6027\u5909\u7570\u3092\u542b\u3080 EGFR \u5909\u7570 EGFR \u611f\u53d7\u6027\u5909\u7570 \u4f5c\u7528\u6a5f\u5e8f EGFR\u3001T790M\u3001\u304a\u3088\u3073\u5909\u7570\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4e0d\u53ef\u9006\u7684\u306b\u963b\u5bb3 EGFR \u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u3092\u9078\u629e\u7684\u306b\u963b\u5bb3 \u6709\u52b9\u6027 \u9032\u884c\u671f\u304a\u3088\u3073 T790M \u5909\u7570\u306b\u5bfe\u3057\u3066\u3088\u308a\u9ad8\u3044\u6709\u52b9\u6027 \u65e9\u671f\u306e EGFR \u5909\u7570 NSCLC \u306b\u6709\u52b9 \u30b3\u30b9\u30c8 \u65b0\u3057\u3044\u88fd\u5264\u304a\u3088\u3073\u7279\u8a31\u306e\u305f\u3081\u3001\u30b3\u30b9\u30c8\u304c\u9ad8\u3044 \u30b3\u30b9\u30c8\u304c\u4f4e\u3044\u3002\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u7248\u304c\u5e83\u304f\u5165\u624b\u53ef\u80fd \u5165\u624b\u53ef\u80fd\u6027 \u4e16\u754c\u4e2d\u3067\u5165\u624b\u53ef\u80fd\u3060\u304c\u3001\u30b3\u30b9\u30c8\u306b\u3088\u3063\u3066\u5236\u9650\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044 \u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u7248\u3092\u542b\u3081\u3001\u5e83\u304f\u5165\u624b\u53ef\u80fd \u5fcd\u5bb9\u6027 \u4e00\u822c\u7684\u306b\u4ee5\u524d\u306eTKI\u3088\u308a\u3082\u5fcd\u5bb9\u6027\u304c\u9ad8\u3044 \u5fcd\u5bb9\u6027\u306f\u9ad8\u3044\u304c\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u91cd\u7be4\u306a\u809d\u81d3\u3078\u306e\u5f71\u97ff\u3092\u4f34\u3046 \u751f\u5b58\u671f\u9593\u306e\u30e1\u30ea\u30c3\u30c8 \u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\uff1a\u7d0418.9\u30f6\u6708\uff08FLAURA\u8a66\u9a13\uff09 \u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\uff1a\u7d0410.9\u30f6\u6708<\/p>\n","protected":false},"excerpt":{"rendered":"
\u30a4\u30ec\u30c3\u30b5250mg\u9320\u306e\u7d39\u4ecb \u30a4\u30ec\u30c3\u30b5250mg\u9320\u306f\u3001\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\uff08NSCLC\uff09\u3068\u547c\u3070\u308c\u308b\u80ba\u304c\u3093\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u308b\u85ac\u3067\u3059\u3002\u3053\u306e\u85ac\u306f\u3001\u304c\u3093\u304c\u8ee2\u79fb\u3057\u3066\u3044\u308b\u3001\u307e\u305f\u306f\u624b\u8853\u3067\u6cbb\u7642\u3067\u304d\u306a\u3044\u4eba\u5411\u3051\u3067\u3059\u3002EGFR\uff08\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50\u306b\u7279\u5b9a\u306e\u5909\u5316\uff08\u5909\u7570\uff09\u304c\u3042\u308b\u60a3\u8005\u306b\u6700\u3082\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002\u30a4\u30ec\u30c3\u30b5\u306e\u6709\u52b9\u6210\u5206\u306f\u30b2\u30d5\u30a3\u30c1\u30cb\u30d6\u3067\u3001\u30a2\u30b9\u30c8\u30e9\u30bc\u30cd\u30ab\u793e\u304c\u88fd\u9020\u3057\u3066\u3044\u307e\u3059\u3002\u30a4\u30ec\u30c3\u30b5250mg\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u9045\u3089\u305b\u305f\u308a\u3001\u6b62\u3081\u305f\u308a\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u4f5c\u7528\u6a5f\u5e8f \u30a4\u30ec\u30c3\u30b5\u306f\u3001\u4f53\u5185\u306eEGFR\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u306b\u3059\u308b\u3053\u3068\u3067\u4f5c\u7528\u3057\u307e\u3059\u3002\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3068\u8ee2\u79fb\u3092\u52a9\u3051\u307e\u3059\u3002\u30a4\u30ec\u30c3\u30b5250mg\u306fEGFR\u3092\u963b\u5bb3\u3057\u3001\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u6b62\u3081\u3001\u816b\u760d\u3092\u7e2e\u5c0f\u3055\u305b\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u304c\u3093\u306e\u7ba1\u7406\u304c\u5bb9\u6613\u306b\u306a\u308a\u3001\u547c\u5438\u56f0\u96e3\u3084\u75b2\u52b4\u306a\u3069\u306e\u75c7\u72b6\u304c\u8efd\u6e1b\u3055\u308c\u307e\u3059\u3002\u30a4\u30ec\u30c3\u30b5250mg\u9320\u306e\u7528\u9014 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