Viropil \u9320\u306e\u7d39\u4ecb Viropil \u9320\u306f\u3001HIV \u5c02\u9580\u533b\u306e\u51e6\u65b9\u306b\u57fa\u3065\u3044\u3066\u6210\u4eba\u304a\u3088\u3073\u9752\u5e74\u306e HIV-1 \u611f\u67d3\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u308b\u6297\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u56fa\u5b9a\u7528\u91cf\u914d\u5408\u5264\u3067\u3059\u3002\u6307\u793a\u901a\u308a\u306b\u901a\u5e38\u306e\u533b\u7642\u3068\u4f75\u7528\u3057\u3066\u670d\u7528\u3059\u308b\u3068\u3001\u4f53\u5185\u306e\u30a6\u30a4\u30eb\u30b9\u91cf\u3092\u6e1b\u3089\u3057\u3001\u514d\u75ab\u56de\u5fa9\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3001HIV \u95a2\u9023\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002 Viropil \u306e\u50cd\u304d \u30a6\u30a4\u30eb\u30b9\u306e\u5236\u5fa1: Viropil \u306f\u4f53\u5185\u3067\u306e HIV \u306e\u5897\u6b96\u80fd\u529b\u3092\u5236\u9650\u3057\u307e\u3059\u3002 \u514d\u75ab\u306e\u4fdd\u8b77: \u30a6\u30a4\u30eb\u30b9\u91cf\u3092\u6e1b\u3089\u3059\u3053\u3068\u3067\u3001\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u3088\u308a\u52b9\u679c\u7684\u306b\u6a5f\u80fd\u3067\u304d\u308b\u3088\u3046\u306b\u3057\u307e\u3059\u3002 \u9577\u671f\u7684\u306a\u7d50\u679c\u306e\u6539\u5584: \u4e00\u8cab\u3057\u3066\u6bce\u65e5\u4f7f\u7528\u3059\u308b\u3068\u3001\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u304c\u8efd\u6e1b\u3055\u308c\u3001\u751f\u6d3b\u306e\u8cea\u304c\u5411\u4e0a\u3057\u307e\u3059\u3002 \u6ce8: Viropil \u306f HIV \u3092\u6cbb\u7642\u3057\u307e\u3059\u304c\u3001\u6cbb\u7652\u3059\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u308c\u81ea\u4f53\u3067\u306f\u611f\u67d3\u3092\u9632\u3050\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u3088\u308a\u5b89\u5168\u306a\u6027\u884c\u70ba\u306e\u5b9f\u8df5\u3068 U=U \u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306f\u4f9d\u7136\u3068\u3057\u3066\u91cd\u8981\u3067\u3059\u3002\u4f5c\u7528\u6a5f\u5e8f Viropil \u306f\u3001\u7570\u306a\u308b\u30af\u30e9\u30b9\u306e\u6297\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u5264\uff08\u901a\u5e38\u306f\u30a4\u30f3\u30c6\u30b0\u30e9\u30fc\u30bc\u963b\u5bb3\u5264\u3068 2 \u3064\u306e\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\/\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u9006\u8ee2\u5199\u9175\u7d20\u963b\u5bb3\u5264 [NRTI] \uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u3082\u306e\u3067\u3059\u3002\u4e00\u7dd2\u306b\u50cd\u304f\u3053\u3068\u3067\u3001\u4ee5\u4e0b\u306e\u52b9\u679c\u304c\u5f97\u3089\u308c\u307e\u3059\u3002 HIV \u304c\u907a\u4f1d\u7269\u8cea\u3092\u8907\u88fd\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3059\u308b\u9175\u7d20\u3067\u3042\u308b\u9006\u8ee2\u5199\u9175\u7d20\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002 HIV \u304c DNA \u3092\u30d2\u30c8\u7d30\u80de\u306b\u633f\u5165\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3059\u308b\u9175\u7d20\u3067\u3042\u308b\u30a4\u30f3\u30c6\u30b0\u30e9\u30fc\u30bc\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002 \u3053\u306e\u4e8c\u91cd\u306e\u4f5c\u7528\u306b\u3088\u308a\u3001\u7d99\u7d9a\u7684\u306b\u670d\u7528\u3059\u308b\u3068\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u304c\u6291\u5236\u3055\u308c\u3001\u30a6\u30a4\u30eb\u30b9\u91cf\u3092\u691c\u51fa\u3067\u304d\u306a\u3044\u30ec\u30d9\u30eb\u306b\u4fdd\u3064\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 \u670d\u7528\u65b9\u6cd5 Viropil \u306f\u3001\u533b\u5e2b\u306e\u6307\u793a\u901a\u308a\u306b\u3001\u6bce\u65e5\u540c\u3058\u6642\u9593\u306b\u670d\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002 \u98df\u4e8b\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u670d\u7528\u3067\u304d\u307e\u3059\uff08\u63d0\u4f9b\u3055\u308c\u3066\u3044\u308b\u30d6\u30e9\u30f3\u30c9\u56fa\u6709\u306e\u6307\u793a\u306b\u5f93\u3063\u3066\u304f\u3060\u3055\u3044\uff09\u3002 \u670d\u7528\u91cf\u3092\u98db\u3070\u3055\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u670d\u7528\u3092\u98db\u3070\u3057\u305f\u308a\u4e2d\u6b62\u3057\u305f\u308a\u3059\u308b\u3068\u3001\u30a6\u30a4\u30eb\u30b9\u91cf\u304c\u5897\u52a0\u3057\u3001\u8010\u6027\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002 \u526f\u4f5c\u7528\u304c\u8d77\u3053\u3063\u305f\u5834\u5408\u306f\u3001\u81ea\u5206\u3067\u4e2d\u6b62\u305b\u305a\u3001HIV \u30b1\u30a2 \u30c1\u30fc\u30e0\u306b\u9023\u7d61\u3057\u3066\u30a2\u30c9\u30d0\u30a4\u30b9\u3084\u8abf\u6574\u3092\u53d7\u3051\u3066\u304f\u3060\u3055\u3044\u3002 \u670d\u7528\u5fd8\u308c 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