Avanafil is a commonly used prescription medication that helps to treat erectile dysfunction (ED). Discovered at Tanabe Seiyaku (now Mitsubishi Tanabe), the molecule falls under the class of medications known as PDE5 or Phosphodiesterase inhibitors.

Avanafil inhibits the PDE5 enzyme, which increases blood flow to the penis during sexual stimulation. It is generally known by its brand name, Stendra, which sells Avanafil tablets in various strengths.
Basic Information
Avanafil molecule helps increase blood circulation to the penis at the time of sexual stimulation. Here is a list of the key information you must keep in mind:

Chemical Structure and Formula: It comes with a unique chemical structure, C23H26ClN7O3. It consists of pyrimidine carboxyamide, chloromethoxy benxylamino group and a pyrimidinylmethyl group.

Discovered In: The molecule was originally discovered at Tanabe Seiyaku (now Mitsubishi Tanabe). Choongwae Pharma, now JW Pharmaceutical, and VIVUS developed and launched it to treat erectile dysfunction (ED).

FDA Approval: The Food and Drug Administration (FDA) approved it for the treatment of ED on April 27, 2012, and the European Medicines Agency (EMA) approved it on June 21, 2013.

Mode of Action: This molecule works by preventing the formation of an enzyme (called PDE5) in the body, which enables the relaxation of specific blood vessels. Avanafil boosts the blood flow to the penis during sexual stimulation, making it easier to arouse and keep an erection.

Uses of Avanafil
Avanafil is primarily used to treat erectile dysfunction (ED). However, it is not a cure for ED, nor does it enhance sexual desire. It also does not prevent sexually transmitted infections (STIs) or affect fertility.

Erectile Dysfunction (ED) is a condition where a man has difficulty achieving or maintaining an erection during sexual arousal. According to records, this issue is quite common. If you experience any of the following symptoms, consult a healthcare professional for guidance:

Flaccid penis
Less sexual desire
Trouble keeping an erection

By effectively addressing symptoms of erectile dysfunction and premature ejaculation, this medication can significantly enhance your sexual well-being, fostering a more fulfilling and intimate relationship with your partner.
How does it work?
Avanafil enhances blood flow to the penis, playing a crucial role in treating erectile dysfunction (ED).

During sexual arousal, the body naturally increases blood flow to the penis to facilitate an erection. However, an enzyme called phosphodiesterase type-5 (PDE5) can interfere with this process, making it difficult to achieve or maintain an erection.

Avanafil works by inhibiting PDE5, allowing for improved blood circulation in the penis when a man is sexually stimulated. While the medication aids in sustaining an erection, it does not induce one on its own. Physical stimulation, such as sexual arousal, is still necessary for it to take effect.
Common Side Effects of Avanafil
This medicine causes common side effects that subside with prolonged use. However, if these side effects persist, it is essential to consult a doctor. The following are some of the serious side effects of Avanafil that require immediate attention from a healthcare professional:

An erection that lasts longer than 3 hours
Sudden loss of vision in one or both eyes
Swollen eyelids
Sudden hearing loss
Ringing in the ears
Allergic reactions
Itching
Heart attack
Low blood pressure
Stroke

Also, some side effects usually do not require any medical professional’s help:

Back pain
Headache
Facial flushing or redness
Upset stomach
Runny or stuffy nose
Blurred vision
Dizziness

There are some rare side effects one can experience after taking Avanafil:

Bladder pain
Arm, back, or jaw pain
Bloody or cloudy urine
Bloating or swelling of the arms, face, hands, lower legs, or feet
Chest pain, discomfort, or tightness
Difficult or labored breathing
Chest tightness or heaviness
Difficult, burning, or painful urination
Fast, irregular, or racing heartbeat or pulse
Frequent urge to urinate
Rapid weight gain
Unusual tiredness or weakness
Sharp back pain just below the ribs
Unusual weight gain or loss

Furthermore, if you experience a sudden loss of vision or hearing after taking Avanafil, do not take any additional doses. Taking similar medications, such as tadalafil (Cialis), sildenafil (Revatio, Viagra), or vardenafil (Levitra) without consulting your doctor can result in serious side effects.
Available Medicines with Avanafil Molecule
Here is a list of brands providing Avanafil tablets:

Brand name
Manufacturer
Strengths

Stendra
Vivus, Inc.
50 mg, 100 mg, 200 mg

Spedra
Vivus, Inc.
50 mg, 100 mg, 200 mg

Avanext
Zydus Cadila
100mg, 200mg

Avanair
Cipla Ltd
100mg, 200mg

Avana-100
Sunrise Remedies
50 mg, 100mg, 200 mg

Take Avanafil tablets by mouth with a glass of water. Follow the instructions on your prescription label and take a dose 15 to 30 minutes before engaging in sexual activity.

Ensure that you adhere to your healthcare professional’s guidelines regarding dosage, and do not take more than one dose per day. Additionally, do not take these tablets more frequently than instructed.
Do not take Avanafil 100mg tablets with any of the following:

Nitrates, including isosorbide dinitrate, amyl nitrite, nitroglycerin, and isosorbide mononitrate
Itraconazole
Riociguat
Tablets that are prescribed to control high blood pressure
Medications to treat HIV infection or AIDS
Grapefruit juice
Carbamazepine
Medicines used to control fungal or yeast infections, such as ketoconazole, fluconazole and voriconazole
Medications for prostate problems
Rifabutin, rifampin or rifapentine
Phenytoin

Please note that this list may not include all possible interactions. It’s important to provide your doctor with a complete list of all medications, over-the-counter drugs, herbs, or dietary supplements you take regularly. Additionally, inform them if you smoke, consume alcohol, or use recreational drugs, as these could interact with your medication.
Frequently Asked Questions

What are the Avanafil brand names?

Stendra and Spedra are the most common brand names for Avanafil.

Where should I keep Avanafil tablets?

Store Avanafil tablets at room temperature between 68°F and 86°F (20°C and 30°C) and away from sunlight.

Who should avoid Avanafil?

Individuals over 50 years of age, or those with coronary artery disease, crowded disc, diabetes, heart disease, hypertension, hyperlipidemia, or NAION (a severe eye condition), should not take this medication.

Can I consume alcohol while taking Avanafil?

Yes, you can consume alcohol while taking Avanafil, but avoid excessive amounts. Excessive alcohol can increase the risk of side effects like headaches, dizziness, increased heart rate, or reduced blood pressure.

What should I know about Avanafil before taking regular doses?

Do not take these medications unless they are prescribed by your healthcare provider. Avoid suggesting that others take or share Avanafil, even if they are experiencing the same condition as you. Furthermore, do not make this medication available to children.

What is the average Avanafil tablet price?

The price of Avanafil tablets can vary. At Indogenmed, the tablet price ranges between $42.46 to $48.25. Always purchase this medication when prescribed by a healthcare provider.

Buy Avanafil tablets from Indogenmed and take control of your sexual life again.

Disclaimer: This content is for information purposes only. It does not replace professional advice. Seek a doctor before consuming Avanafil.

Reference Links:

https://medlineplus.gov/druginfo/meds/a614010.html#brand-name-1

https://my.clevelandclinic.org/health/drugs/19107-Avanafil-tablets

https://www.mayoclinic.org/drugs-supplements/Avanafil-oral-route/description/drg-20075594

https://www.webmd.com/drugs/2/drug-165587/stendra-oral/details