Danazol
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Danazol is a prescription medication used to treat a variety of conditions, primarily related to hormonal imbalances or immune system issues. It is classified as a synthetic steroid and works by altering the production and utilization of certain hormones in the body.
Uses of Danazol for Endometriosis:
Danazol helps reduce symptoms of endometriosis, a condition in which tissue lining the uterus grows outside the uterus. It works by suppressing the hormones responsible for the menstrual cycle, reducing pain, and slowing abnormal tissue growth.
Fibrocystic Breast Disease:
Used to alleviate the pain and tenderness associated with non-cancerous breast lumps. Hereditary Angioedema: Danazol helps prevent attacks of swelling in people with this genetic condition by increasing the levels of specific proteins in the blood.
Mechanism of Action
Danazol reduces the production of hormones like estrogen and progesterone by acting on the pituitary gland.
This results in: Suppression of ovarian function—reduction in hormonal stimulation of specific tissues, such as the endometrium and breast tissue. Increased levels of specific blood proteins help prevent swelling in hereditary angioedema.
Dosage and Administration:
Danazol is available as capsules and is typically taken 1-4 times a day, depending on the condition being treated. It should be taken at the same time each day, with or without food. Dosage varies based on the severity of the condition and the patient’s response to treatment.
Side Effects Common side effects include:
Weight gain Acne Greasy skin or hair Flushing or sweating Serious side effects may include: Mood changes Yellowing of the skin or eyes (jaundice) Unusual bleeding or bruising If any severe side effects occur, medical attention should be sought immediately.
Precautions
Danazol should not be used during pregnancy as it can harm the fetus. Patients with severe liver or kidney problems should avoid using danazol. Danazol can interact with blood thinners, cholesterol-lowering medications, and other drugs.