Tagrisso 80 Mg Tablets

Tagrisso 80mg is a prescription medicine containing Osimertinib, which is widely used to treat non-small cell lung cancer (NSCLC). It belongs to the tyrosine kinase inhibitor(TKI) class of medications and works well for patients with Epidermal Growth Factor Receptor (EGFR) mutation-positive NSCLC.

Tagrisso works by blocking abnormal EGFR activity, thereby slowing or stopping the growth of cancer cells. Manufactured by AstraZeneca, it has shown improvement in survival rates in patients with advanced lung cancer.

This is available only through prescription and should be consumed under medical supervision only.

Key Benefits of Tagrisso 80

Some of the key benefits of Tagrisso 80 (Osimertinib) are as follows:

• Tagrisso mainly targets the epidermal growth factor receptor (EGFR) mutations, preferably among non-small cell lung cancer (NSCLC).
• It remains effective even in cases where patients have developed resistance to earlier EGFR-targeted therapies, offering hope to patients with limited availability of treatment options.
• Taking this medicine orally once daily helps prevent the spread of cancer further to the brain and other body parts, making it especially beneficial for patients with metastatic NSCLC.
• When taken in the prescribed dosage, the drug is generally well-tolerated. Its side effects, including skin rash and diarrhoea, are manageable, making it a suitable long-term treatment option.

How Does Tagrisso 80 Work?

Tagrisso contains the active ingredient Osimertinib, a type of cancer treatment known as a tyrosine kinase inhibitor (TKI). It specifically targets certain proteins involved in the growth and spread of cancer cells, making it a highly effective option for treating specific types of lung cancer. This medicine further blocks the activity of EGFR, which further exerts control over the growth and division of cells.

In non-small cell lung cancer (NSCLC), EGFR mutations cause the receptor to become overactive, leading to uncontrolled cancer cell growth. Because of the distinguishing feature of inhibiting EGFR, Osimertinib can reduce growth and prevent further spreading of cancer.

Dosage and Administration of Tagrisso 80

The table below displays the recommended dosage of Tagrisso 80 in terms of indication:

Indicator	Dosage Recommended for Tagrisso	Treatment Duration
Adjuvant Treatment of EGFR Mutation – Positive NSCLC	Take Tagrisso 80mg tablet orally once daily with or without food.	For 3 years or until the disease occurs again.
First-Line Treatment of EGFR Mutation- Positive Metastatic NSCLC	Oral consumption of the Tagrisso tablet 80mg daily with or without food	Until disease progression or unacceptable toxicity occurs.
First-line Treatment of EGFR Mutation-Positive Locally Advanced or Metastatic NSCLC	Take one 80mg tablet orally once daily, with or without food, in combination with platinum-based chemotherapy.	Until disease progression or unacceptable toxicity occurs.
Earlier Treated EGFR T790M Mutation – Positive Metastatic NSCLC	Consume 80mg tablet orally daily with or without food	Until disease progression or unacceptable toxicity occurs.

Patients with difficulty swallowing or who require nasogastric tube administration can take this medicine as a whole with water. If any dose gets missed, do not worry about taking the missed dose. Instead, take the next scheduled dose.

Strengths and Substitutes of Tagrisso 80

Following is a detailed table of strengths and substitutes of the Tagrisso tablet:

Medication	Dosage	Appearance	Markings	Substitutes
Tagrisso	40mg	Oval, beige, biconvex	“AZ 40” on one side, plain on the other	No substitutes available
Tagrisso	80mg	Oval, beige, biconvex	“AZ 80” on one side, plain on the other	Keytruda, Opdivo

Side Effects of Tagrisso 80

Similar to other medicines, Tagrisso 80 has also several side effects. Make sure to inform your healthcare provider if any side effects bother you for a prolonged period. Here is the list of the most common side effects of Tagrisso 80:

• Diarrhoea

• Blood disorders
• Pain in muscles or bones
• Rash
• Dry skin
• Changes in the nail
• Tiredness
• Mouth sores

On the other hand, here are some of the most serious forms of side effects, although they may be less common. Let us look into those effects in detail below:

• Allergic Reactions

Tagrisso 80 might cause severe allergic reactions. If any of the following symptoms occur, stop taking Tagrisso right away and consult your doctor:

1. Racing heart
2. Problems with breathing or wheezing
3. Swollen lymph nodes
4. Fever or a sudden feeling of illness
5. Swelling of lips, mouth, face, throat, and tongue
6. Trouble in swallowing or throat tightness
7. Nausea or vomiting
8. Skin rash, itching, or red bumps on the skin, commonly known as hives
9. Cramps inthe  stomach
10. Joint pain
11. Dizziness, fainting, or light-headedness
12. Changes in Heart Rhythm

Taking Tagrisso 80mg daily may affect heart rhythm, potentially causing irregular heartbeat, fainting, or, in rare cases, heart failure. Individuals with pre-existing heart conditions or those taking heart-related medications are at a higher risk. Seek medical help if you face any of the following signs of heart rhythm changes:

1. Shortness of breath
2. Chest pain
3. Lightheaded, dizzy, or fainting
4. Sudden changes in your heart rhythm, which can be slow, fast, or a skipped heartbeat

• Issues in Eyes

Taking Tagrisso 80 can cause swelling in the eyes. Ask for medical help immediately if you face any of the following symptoms:

1. Watery eyes
2. Blurry vision
3. Pain in the eyes
4. Sensitivity to light
5. Swelling or causing redness in the eyes

Safety and Precautions of Tagrisso 80

Understanding Tagrisso 80’s safety and precautions is essential for proper usage and minimizing risks. Let us explore the safety and precautions feature in detail below:

• Alcohol: Whether you should consume alcohol with the Tagrisso 80mg tablet, consult your doctor immediately.
• Breastfeeding: Do not take the Tagrisso 80mg tablet during breastfeeding. According to several studies, the drug might pass into the breastmilk and affect the baby’s health.
• Pregnancy: Tagrisso 80mg is not safe for use during pregnancy, as it can cause harm to the developing baby. Your doctor will carefully evaluate the risks and benefits before prescribing this medication. If you are pregnant or planning to conceive, discuss alternative treatment options with your healthcare provider.
• Kidney: Patients with kidney disorders can consume Tagrisso 80mg tablets, and there is no need for adjustment of the medicine.
• Driving: Usually, Tagrisso 80mg does not create a significant impact on your ability to drive.
• Liver: Patients with liver disease can easily consume Tagrisso 80mg tablets. There is no need to adjust dosages.

Frequently Asked Questions

• What is the primary use of Tagrisso 80mg tablet?

Tagrisso 80mg tablet is primarily used for treating lung cancer.

• What are the important things I should consider while taking Tagrisso 80mg tablet?

While taking Tagrisso 80mg, regular doctor visits are essential to ensure effective treatment. Additionally, routine monitoring of blood tests, lipid levels, and weight is recommended.

Both men and women should use effective contraception during treatment to prevent pregnancy, as Tagrisso 80mg may cause harm to a developing baby.

• Is non-small cell lung cancer common?

Non-small cell lung cancer is quite common and it constitutes about 80-85% of all lung cancers. Lung cancer, generally, is the second most common cancer among both men and women and non-small cell lung cancer is the most prevalent kind.

• Does Tagrisso 80mg tablet consumption cause bleeding?

Yes, taking Tagrisso 80mg may lead to a significant drop in platelet count, which are blood cells responsible for clotting. A low platelet count increases the risk of easy bruising and unexpected bleeding. If you face any unexplained bleeding suddenly, make sure to consult your doctor.

• What are the common side effects of Tagrisso 80mg tablet?

Some of the most common side effects of Tagrisso 80mg tablets are rashes, diarrhoea, dry skin, nail toxicity, fatigue, reduced appetite, low count of blood cells, and others. If any of these side effects persist for a long time or worsen further, make sure to consult your doctor.

• What should I do if I miss a dose of the Tagrisso tablet?

If you miss a dose of the Tagrisso tablet, skip it and continue following your normal schedule.

• What are the different foods should I avoid while taking Tagrisso 80mg tablets?

To ensure the effective absorption and action of Tagrisso 80mg, avoid consuming grapefruit and grapefruit juice as it may interfere with the metabolism of the drug, affecting its effectiveness. For personalized dietary recommendations, consult your doctor or a nutritionist to ensure a balanced and safe diet during treatment.

• What is the ideal time of day to consume Tagrisso 80mg tablet?

Take Tagrisso 80mg tablet as per your doctor’s advice. Swallow the whole tablet with water and make sure to consume it same time every day.

• Does the Tagrisso tablet help in shrinking tumours?

Yes, the Tagrisso tablet helps in shrinking tumours among patients and slows down the cancer symptoms.

• Can Tagrisso tablets be given to patients facing kidney problems?

For patients facing kidney problems, Tagrisso 80mg tablets are safe to consume. There is no need to make adjustments in dosages.

• Is taking antibiotics normal with Tagrisso tablets?

Taking Tagrisso 80mg tablets with antibiotics can reduce the effectiveness of the medicine. Thus, inform your doctor about all medicines you are taking including over-the-counter medicines you are taking or have taken earlier.

• Does Tagrisso 80mg tablet cause loss of hair?

Though it is quite uncommon, Tagrisso 80mg can cause hair loss. If you experience more hair fall, consult your doctor right away.

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Disclaimer: Tagrisso 80mg might not be suitable for every individual. It is thus important to understand its potential side effects in comparison with other treatments. Make sure to take this medicine only under the supervision of a qualified healthcare professional.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/208065s030lbl.pdf

https://www.astrazeneca.com/media-centre/press-releases/2024/tagrisso-improved-pfs-in-stage-iii-lung-cancer.html

https://www.tagrisso.com/late-stage-egfr-nsclc/about-tagrisso.html

https://www.webmd.com/drugs/2/drug-170434/tagrisso-oral/details

https://www.ncbi.nlm.nih.gov/books/NBK596656/