Ambrisentan

Ambrisentan is a medicine used to treat pulmonary arterial hypertension (PAH). PAH is a condition where the blood pressure in the arteries of the lungs becomes too high, making it hard for the heart to pump blood.

Ambrisentan helps relax and widen the blood vessels in the lungs. This lowers lung blood pressure, improves breathing, and helps patients be more active in daily life.

It is a long-term treatment and should only be taken under a doctor’s supervision.

Uses of Ambrisentan

Ambrisentan is used for:

• Pulmonary arterial hypertension (PAH)
• Improving exercise capacity in PAH patients
• Slowing disease progression and reducing symptoms

How Ambrisentan Works

Ambrisentan belongs to a group of medicines called endothelin receptor antagonists (ERAs).

It works by:

• Blocking endothelin, a substance that causes blood vessels to tighten
• Relaxing lung blood vessels
• Lowering pressure in pulmonary arteries
• Reducing strain on the heart

This helps improve blood flow and breathing.

How to Take Ambrisentan

• Take Ambrisentan exactly as prescribed by your doctor
• Usually taken once daily, with or without food
• Swallow the tablet whole with water
• Take it at the same time every day

Do not crush or chew the tablet.

Common Side Effects

Some people may experience:

• Swelling in the legs or ankles
• Headache
• Flushing
• Stuffy nose
• Tiredness

These side effects are usually mild and manageable.

Serious Side Effects (Seek Medical Help Immediately)

• Liver problems (yellowing of skin or eyes)
• Severe fluid retention
• Shortness of breath that worsens
• Low red blood cell count (anemia)

Safety Precautions

• Pregnancy: Not safe during pregnancy; strict contraception is required
• Breastfeeding: Not recommended
• Liver: Regular liver function tests are needed
• Anemia: Blood counts should be monitored
• Alcohol: Avoid or limit alcohol use

Drug Interactions

Tell your doctor about all medicines and supplements you take. Ambrisentan may interact with:

• Cyclosporine
• Other PAH medicines
• Some blood pressure medicines

These interactions may require dose adjustments.

Storage Instructions

• Store below 30°C
• Keep away from moisture and sunlight
• Keep out of reach of children
• Do not use expired tablets

FAQs

Q1. What is Ambrisentan used for?
It is used to treat pulmonary arterial hypertension and improve breathing and activity levels.

Q2. Is Ambrisentan a blood pressure medicine?
It lowers blood pressure specifically in the lungs, not the general body blood pressure.

Q3. How long does Ambrisentan take to work?
Some people notice improvement in a few weeks, but full benefits may take longer.

Q4. Can Ambrisentan cure PAH?
No. It helps manage symptoms and slow progression, but does not cure PAH.

Fact Box

• Drug Name: Ambrisentan
• Drug Class: Endothelin receptor antagonist
• Used For: Pulmonary arterial hypertension (PAH)
• Dose: Once daily (as prescribed)