When it comes to medications for erectile dysfunction (ED), you have probably heard of the "little blue pill" or Viagra- but did you know there are different options available? Two of the most common active ingredients are Tadalafil and Sildenafil, and while they both help with ED, they work in slightly different ways.
This blog breaks down the comparison between Tadalafil vs Sildenafil in simple terms to help you understand their benefits, side effects, dosages, and more. Let us start by getting to know each of them a bit better.
Overview of Both Tadalafil and Sildenafil
Tadalafil is the active ingredient in Cialis, which was approved a few years after Viagra. It is sometimes called the "weekend pill" because its effects can last up to 36 hours. Tadalafil can be taken as needed or daily at a lower dose.
How Do Tadalafil and Sildenafil Work?
Relax the blood vessels in the penis
Increase blood flow to the erectile tissue
Make it easier to get and keep an erection
Sildenafil vs Tadalafil: Key Differences
Duration of Action
Sildenafil: Works for about 4-6 hours
Tadalafil: Can work for up to 36 hours
Food Interactions
Sildenafil: Works best when taken on an empty stomach; high-fat meals can delay its effect.
Tadalafil: Can be taken with or without food; food does not significantly impact its effectiveness.
Dosing Options
Sildenafil: Usually taken as needed.
Tadalafil: Can be taken as needed or daily in a lower dose.
Onset of Action
Sildenafil: Typically begins working within 30-60 minutes.
Tadalafil: Usually begins working within 30-45 minutes, but can take up to 2 hours to reach full effect.
Sildenafil vs Tadalafil: How Much to Consume and When?
Sildenafil:
Typical Starting Dose: 50mg
Dose Range: 25mg to 100mg
Usually taken 30-60 minutes before sexual activity
Should not be taken more than once per day
Works best when taken on an empty stomach
Tadalafil:
For As-needed Use: Typical dose is 10mg, with a range of 5mg to 20mg
For Daily Use: Typical dose is 2.5mg or 5mg
An as-needed dose should be taken at least 30 minutes before sexual activity.
The daily dose is taken at the same time each day, regardless of sexual activity.
Can be taken with or without food
Men with kidney or liver problems usually need lower doses of either medication.
Age is also a factor – men over 65 typically start at lower doses because their bodies may process the medications more slowly.
The right tadalafil & sildenafil dosage depends on various factors, including your health, other medications, and how your body responds.
Always follow your doctor’s recommendations for the best results.
Side Effects of Sildenafil & Tadalafil: Which One is Safer?
Both medications are generally safe when used as prescribed, but like all medications, they can cause side effects. Most side effects are mild and temporary. Understanding the side effects of Tadalafil vs Sildenafil can help you make an informed choice.
Common Side Effects of Both:
Headache
Flushing (redness and warmth in the face)
Indigestion or upset stomach
Nasal congestion
Dizziness
Back pain
Muscle aches
Unique to Sildenafil:
Visual changes (blue tinge to vision, increased light sensitivity)
These visual side effects are rare but more common with Sildenafil than with Tadalafil.
Unique to Tadalafil:
Because it stays in your system longer, side effects may last longer.
May cause limb pain more frequently than Sildenafil.
Serious Side Effects (Rare but Important to Know):
Priapism (an erection lasting more than 4 hours) requires immediate medical attention
Sudden hearing loss
Sudden vision loss
Severe drop in blood pressure, especially when combined with certain other medications
Sildenafil vs Tadalafil: Which One Acts Faster
Sildenafil:
Typically begins working within 30-60 minutes
Peak effect usually occurs within 60-120 minutes
Taking it on an empty stomach helps it work faster
Tadalafil:
Usually begins working within 30-45 minutes
It can take up to 2 hours to reach full effect
Food does not significantly delay the onset of action
Sildenafil vs Tadalafil: Which One is Right for You
Prefer spontaneous sexual activity without planning.
Sexually active multiple times per week.
Want the option of daily dosing for continuous coverage
Find the idea of not having to plan medication before intimacy appealing.
You plan sexual activity in advance
You want a medication that clears your system more quickly
You have less frequent sexual activity (once a week or less)
You prefer taking medication only when needed
You are concerned about cost (generic Sildenafil is typically less expensive)
| Medication | Brand Names | Available Strengths |
| Sildenafil | Viagra, Revatio, Suhagra, Kamagra, Cenforce, etc. | 25 mg, 50 mg, 100 mg (20 mg for PAH) |
| Tadalafil | Cialis, Adcirca, Vidalista, Tadacip, etc. | 2.5 mg, 5 mg, 10 mg, 20 mg, (40 mg for PAH) |
Final Thoughts
Tadalafil and Sildenafil have helped millions of men worldwide overcome erectile dysfunction and enjoy healthier intimate relationships. The best medication is the one that works effectively for you, has minimal side effects, and fits seamlessly into your lifestyle.
When comparing Tadalafil vs Sildenafil, keep in mind that effectiveness varies from person to person. Some men respond better to one medication than the other. If the first medication you try does not work well, doctors often suggest trying the alternative.
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Frequently Asked Questions
Which is better, Sildenafil or Tadalafil?
Neither is universally «better» — they work similarly but have different durations and timing. Sildenafil lasts 4-6 hours, while Tadalafil lasts up to 36 hours. The best choice depends on how your body responds to each medication.
Is Tadalafil more expensive than Sildenafil?
Brand-name Cialis (Tadalafil) is typically more expensive than brand-name Viagra (Sildenafil). Generic versions of both are available and less costly, but generic Tadalafil still tends to cost more than generic Sildenafil.
Which is better for daily use, Sildenafil or Tadalafil?
Tadalafil is approved for daily use in low doses (2.5mg or 5mg), whereas Sildenafil is not typically prescribed for daily use. If you prefer a daily regimen to stay ready for sexual activity at any time, Tadalafil may be the better option.
What are the common side effects of Sildenafil and Tadalafil?
Common side effects for both include flushing, headache, nasal congestion, indigestion, and back pain. Sildenafil is more commonly associated with visual disturbances (a bluish tint to vision), while Tadalafil is more frequently associated with limb pain.
How do Sildenafil and Tadalafil affect blood pressure?
Both medications can lower blood pressure slightly, which is usually not a problem for most men. However, they can cause a dangerous drop in blood pressure when combined with nitrates or alpha-blockers. Always discuss your complete medical history with your doctor before starting either medication.
Is one better for specific age groups than the other?
There is no clear age-related preference for either medication. However, older men (over 65) may be started on lower doses of either drug, as they might be more sensitive to side effects.
Can I get Sildenafil or Tadalafil over the counter?
In most countries, both medications require a prescription. In the UK, Sildenafil is available over the counter as Viagra Connect, but Tadalafil still requires a prescription. Always consult with a healthcare provider before taking these medications, even if you can access them without a prescription in your country.
How do I know which one is right for me, Sildenafil or Tadalafil?
The best way to determine which medication is proper for you is to discuss your lifestyle and medical history with your healthcare provider. Some men find that one medication works better for them than the other, or that they experience fewer side effects with one versus the other. Your doctor might recommend trying both to see which works best for you.
Are there any long-term effects of using Sildenafil or Tadalafil?
Both medications have been studied extensively and are generally considered safe for long-term use when prescribed appropriately. However, it is vital to address the underlying causes of ED when possible, rather than relying solely on medication.
Does Tadalafil help with BPH (enlarged prostate) as well as ED?
Yes, Tadalafil is FDA-approved to treat both erectile dysfunction and symptoms of benign prostatic hyperplasia (BPH), such as difficulty urinating. Sildenafil does not have this additional approval.
Reference:
https://www.webmd.com/drugs/2/drug-7418/Sildenafil-oral/details
https://pubmed.ncbi.nlm.nih.gov/19817982/
https://www.mayoclinic.org/drugs-supplements/Sildenafil-oral-route/description/drg-20066989
https://my.clevelandclinic.org/health/drugs/19136-Tadalafil-tablets-erectile-dysfunction-bph
