Alpelisib is a cancer medicine mainly used to treat a certain type of advanced breast cancer. It is given to patients whose cancer is hormone receptor-positive (HR+), HER2-negative, and has a specific genetic change called a PIK3CA mutation.

Alpelisib is a targeted therapy, not chemotherapy. It works by blocking a pathway that cancer cells use to grow and survive. This helps slow down or control the spread of cancer.

It is usually prescribed with another medicine, fulvestrant, and should be taken only under a doctor’s supervision.

Uses of Alpelisib

Alpelisib is used for:

• HR-positive, HER2-negative advanced or metastatic breast cancer
• Breast cancer with a PIK3CA gene mutation
• Patients whose cancer has worsened after hormone (endocrine) therapy

Doctors confirm the PIK3CA mutation through a lab test before starting treatment.

How Alpelisib Works

Alpelisib belongs to a group of medicines called PI3K inhibitors.

It works by:

• Blocking the PI3K protein that helps cancer cells grow
• Stopping signals that allow cancer cells to survive
• Slowing down cancer progression

By targeting this specific pathway, Alpelisib helps control cancer more precisely.

How to Take Alpelisib

• Take Alpelisib exactly as prescribed by your doctor
• Usually taken once daily with food
• Swallow the tablet whole with water
• Take it at the same time each day

Do not crush or chew the tablet.

Common Side Effects

Some people may experience:

• High blood sugar levels
• Skin rash
• Diarrhea
• Nausea
• Tiredness
• Loss of appetite
• Mouth sores

These side effects are common and can often be managed with medical care.

Serious Side Effects (Seek Medical Help Immediately)

• Very high blood sugar
• Severe skin rash
• Persistent diarrhea
• Signs of infection
• Breathing problems

Tell your doctor right away if any side effects become severe or unusual.

Safety Precautions

• Diabetes: Blood sugar levels must be monitored regularly
• Pregnancy: Not safe during pregnancy
• Breastfeeding: Not recommended during treatment
• Liver & Kidney: Regular tests may be required
• Alcohol: Avoid or limit alcohol use

Drug Interactions

Tell your doctor about all medicines and supplements you take. Alpelisib may interact with:

• Certain diabetes medicines
• Steroids
• Some antibiotics or antifungals
• Herbal products

These interactions can increase side effects or reduce effectiveness.

Storage Instructions

• Store below 30°C
• Keep away from moisture and sunlight
• Keep out of reach of children
• Do not use expired tablets

FAQs

Q1. What is Alpelisib used for?
It is used to treat advanced breast cancer with a PIK3CA mutation.

Q2. Is Alpelisib chemotherapy?
No. It is a targeted therapy that blocks a specific cancer growth pathway.

Q3. Why is blood sugar monitoring important?
Alpelisib can raise blood sugar levels, so regular monitoring is needed.

Q4. Is Alpelisib taken alone?
No. It is usually taken with fulvestrant.

Fact Box

• Drug Name: Alpelisib
• Drug Class: Targeted anticancer therapy
• Category: PI3K inhibitor
• Used For: HR-positive, HER2-negative advanced breast cancer