Cervical Cancer

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Molecule: Bevacizumab
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Cervical cancer is a cancer that begins in the cervix, which connects the uterus to the vagina. In most cases, it develops slowly over time. Many cervical cancers start as pre-cancer changes (abnormal cells on the cervix) that can be found early through screening and treated before they turn into cancer.

A major cause linked to cervical cancer is long-term infection with certain types of human papillomavirus (HPV). HPV is common, and most infections clear on their own, but some high-risk types can cause cell changes that may lead to cancer if not detected early.

Why cervical cancer matters

Cervical cancer can often be prevented or found early with:

  • HPV vaccination
  • Regular screening (Pap test and/or HPV test)
    Early detection usually means simpler treatment and better outcomes.

Common Symptoms

Early cervical cancer may not cause symptoms. When symptoms appear, they can include:

Common symptoms

  • Bleeding between periods
  • Bleeding after sex
  • Bleeding after menopause
  • Unusual vaginal discharge (watery, foul-smelling, or blood-stained)
  • Pelvic pain or pain during sex

Symptoms that can appear in advanced stages

  • Persistent pelvic or back pain
  • Swelling in legs
  • Difficulty passing urine or blood in urine (in some cases)
  • Weight loss and severe tiredness

Risk Factors

Cervical cancer risk can increase with:

HPV and sexual health factors

  • Long-term high-risk HPV infection
  • Early sexual activity or multiple sexual partners (increases HPV exposure)
  • A partner who has had multiple partners

Other health and lifestyle factors

  • Smoking
  • Weak immune system (for example, untreated HIV)
  • Long-term use of certain contraceptives (risk can vary, doctor-guided)
  • Not getting regular cervical screening
  • Having multiple full-term pregnancies (in some cases)

Screening and Early Detection

Screening helps detect pre-cancer changes before cancer develops.

Common screening tests

  • Pap test (Pap smear)
  • HPV test
  • Visual inspection methods in some settings (doctor-guided)

Diagnosis

If screening is abnormal or symptoms suggest a problem, doctors may advise:

Tests commonly used

  • Pelvic examination
  • Colposcopy (a closer look at the cervix with a special instrument)
  • Biopsy (most important to confirm cancer)
  • Imaging tests (CT, MRI, PET-CT) to check spread and stage (if cancer is confirmed)

Treatment

Treatment depends on the stage, tumor size, and overall health.

Early-stage cervical cancer

  • Surgery to remove the cancer (type depends on stage)
  • In some cases, fertility-sparing options may be considered (specialist decision)

Locally advanced cervical cancer

  • Radiation therapy
  • Chemotherapy, along with radiation (often used together)

Advanced or recurrent cervical cancer

  • Chemotherapy
  • Targeted therapy or immunotherapy in selected cases
  • Palliative/supportive care to improve comfort and quality of life

Supportive Care During Treatment

Many patients may need support for:

  • Nausea and vomiting
  • Pain control
  • Infection prevention support (as advised)
  • Nutrition and energy support
  • Anemia or low blood counts (in selected cases)

Prevention

HPV vaccination

Helps protect against common high-risk HPV types and reduces cervical cancer risk.

Regular screening

Screening can detect changes early, often before cancer forms.

Safe practices

  • Safer sex practices can lower HPV risk
  • Avoid smoking, as it increases risk and affects healing

When to Seek Medical Help Quickly

Get medical help urgently if you have:

  • Heavy vaginal bleeding
  • Bleeding after menopause
  • Severe pelvic pain with fever
  • Weakness, dizziness, or fainting due to bleeding
  • Rapidly worsening symptoms during treatment

Specialists to Consult

  • Gynecologist
  • Gynecologic oncologist (cervix cancer specialist)
  • Radiation oncologist
  • Medical oncologist

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