AVAILABLE MEDICINE FOR Bictegravir, Emtricitabine, and Tenofovir Alafenamide


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Introduction to Bictegravir, Emtricitabine, and Tenofovir Alafenamide


Taffic Tablet has three active ingredients: bictegravir, emtricitabine, and tenofovir alafenamide.This medicine plays an important role in the treatment of HIV-1 infection. This combination in a single tablet that makes treatment easier and helps patients to stick their medicine.


Every medication has its own purpose. For example, bictegravir prevents the virus from entering your DNA cells, whereas tenofovir alafenamide and emtricitabine prevent the virus from multiplying.


This treatment helps keep the virus under control for a long time and improves quality of life. This treatment marks an important advance in the fight against HIV/AIDS.


Similarly, Biktarvy is another antiretroviral medication that combines the same active ingredients—Bictegravir, Emtricitabine, and Tenofovir Alafenamide. It works as an alternative to Taffic tablet, offering same benefits in the management of HIV-1 infection.


How Does it Works? 

Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Taffic tablet works together to fight against HIV virus.

Bictegravir blocks the HIV integrase enzyme, preventing the virus from entering into DNA.

Emtricitabine and Tenofovir Alafenamide both blocks the reverse transcriptase enzyme, which is important for converting viral RNA into DNA. They work by imitating natural nucleotides, which stops the DNA chain from growing too soon.

These three components prevent the virus from replicating and spreading. This reduces the viral load and helps manage HIV infection.

Dosage of Bictegravir, Emtricitabine, and Tenofovir Alafenamide


Adults and Children (weighing at least 25 kg):- Take one tablet of Bictegravir, Emtricitabine, and Tenofovir Alafenamide once daily. Each tablet has 50 mg of Bictegravir, 200 mg of Emtricitabine, and 25 mg of Tenofovir Alafenamide. This simple dosage helps reduce the number of pills patients need to take.


Children (weighing between 14 kg and less than 25 kg):- The dosage depends on body weight and may involve a lower strength tablet or smaller dose. Always follow a healthcare provider's instructions for safe and effective treatment.


You can take this medication with or without food. There are no specific dietary rules, making it easy to fit into your daily life.


Timing of Dosage:-

  • Take the medication at the same time each day to keep drug levels steady in your body. 

  • This helps it work better and lowers the chance of the virus becoming resistant. 

  • If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. 

  • Do not take two doses at once.



Side Effects of  Bictegravir, Emtricitabine, and Tenofovir Alafenamide

  • Common Side effect

    • Nausea

    • Diarrhea

    • Headache

    • Fatigue

  • Rare but Serious

    • Lactic Acidosis

    • Hepatomegaly

    • Renal Toxicity

  • Long-Term Use Considerations

    • Bone Density Loss

    • Renal Function Impact


FDA and EMA Approval of Biktarvy

Biktarvy and Taffic Tablet have received approval from major regulatory authorities, ensuring their safety and efficacy for treating HIV-1 infection.

Biktarvy

  • FDA (U.S. Food and Drug Administration): Approved for use in the United States as a once-daily, single-tablet regimen for the treatment of HIV-1 infection in adults and pediatric patients.

  • EMA (European Medicines Agency): Approved for use in the European Union for the same indications, following rigorous evaluation of its clinical effectiveness and safety profile.

Taffic Tablet:

Regulatory Approvals: Similar to Biktarvy, Taffic Tablet has been approved by various national regulatory agencies, including the FDA and EMA. It is used based on its demonstrated efficacy and safety in clinical trials.

Both Biktarvy and Taffic Tablet are widely prescribed according to local treatment guidelines, which may vary based on regional health regulations and clinical data.

Drug Interaction


Biktarvy and Taffic Tablet can interact with many medications, including some that should not be taken together. It is important to avoid using them with certain drugs that may reduce their effectiveness or raise the risk of side effects.

Strong CYP3A4 Inducers:

  • Rifampin

  • Carbamazepine

  • Phenytoin

Drugs that Increase Side Effects:

  • Ketoconazole

Contraindicated Medications:

  • Specific antiretroviral agents (varies)

Interactions with Darunavir/Cobicistat:

  • Darunavir

  • Cobicistat


Precautions and Warning
  • Risk of developing lactic acidosis, monitor for symptoms such as muscle pain, difficulty breathing, and abdominal discomfort.

  • Patients with liver or kidney issues should be closely monitored during treatment.

  • Be cautious with high blood pressure management.

  • Use sun protection due to potential increased sensitivity to sunlight.

  • Consult a healthcare provider about interactions with medications.


Future research on Bictegravir, Emtricitabine, and Tenofovir Alafenamide will focus on several important areas. Clinical trials are currently testing how well these drugs work over the long term in keeping the virus suppressed and preventing drug resistance. Researchers are also looking for new drug combinations to make treatment more effective and easier to follow. They are investigating new ways to deliver these drugs, such as extended-release forms, long-acting injections, and transdermal patches. These efforts aim to make HIV treatment with Taffic Tablet more convenient and effective.


Approval Links


www.gilead.com

https://www.ema.europa.eu/en/medicines/human/EPAR/biktarvy