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Priligy Tablets

Priligy Tablets

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Product Name & Information

Product Name: Priligy Tablets

Active Ingredient: Dapoxetine Hydrochloride

Manufacturer: Menarini Group (in association with Janssen-Cilag)

Prescription Status: Prescription-only medication

Drug Class: Selective Serotonin Reuptake Inhibitor (SSRI)

Overview:

Priligy is a fast-acting, short-duration SSRI formulated to treat premature ejaculation (PE) in adult men. It is available in two dosage strengths: Priligy 30mg and Priligy 60 mg. Unlike traditional SSRIs used for depression, Priligy is designed for on-demand use, making it convenient for men who wish to improve sexual performance when needed without committing to daily medication.

Priligy helps delay ejaculation, enhance sexual satisfaction, and reduce the emotional strain that often accompanies PE. As the original innovator brand, Priligy is distinct from generic Priligy, which refers to Dapoxetine-based products manufactured by other pharmaceutical companies.

Whether looking to understand how Priligy tablets work or planning to buy Priligy online, this page provides a complete overview to help patients and healthcare professionals make informed choices.

Key Benefits

  • Provides rapid onset of action within 1 to 3 hours

  • Increases intravaginal ejaculation latency time (IELT) by 2 to 3 times in most users

  • Enhances control over ejaculation and reduces performance anxiety

  • Taken only when needed; no requirement for daily dosing

  • Available in two flexible strengths: Priligy 30mg and Priligy 60 mg

  • Improves sexual satisfaction for both partners

  • Can be used alongside medications for erectile dysfunction (ED)

  • Offered under both innovator and generic Priligy labels for cost flexibility

  • Widely accessible through licensed pharmacies and online channels

How Priligy Works

Role of Serotonin in Ejaculation

Ejaculation is controlled by a neurological pathway involving the brain, spinal cord, and chemical messengers called neurotransmitters. Serotonin (5-HT) is a key neurotransmitter in this process. In men with PE, low serotonin activity is commonly observed in areas of the brain that regulate the ejaculatory reflex.

How Dapoxetine (Priligy) Acts

Priligy contains Dapoxetine, a short-acting SSRI that works by inhibiting the serotonin transporter (SERT). This action increases serotonin levels in the synaptic cleft — the space between neurons — which results in:

  • Enhanced serotonin signaling in the ejaculatory centers of the brain and spinal cord

  • Improved voluntary control over ejaculation

  • Reduced sensitivity to sexual stimulation and psychological distress

Pharmacodynamic Advantages

Compared to conventional SSRIs, Priligy has a unique pharmacokinetic profile:

  • Time to peak plasma concentration: 1 to 3 hours

  • Duration of action: Approximately 4 to 6 hours

  • Elimination half-life: Short, resulting in full clearance within 24 hours

These properties allow for on-demand use of Priligy tablets, making them ideal for patients who prefer not to take medication daily.

Dosage & Administration

Priligy is available in two distinct dosage strengths: Priligy 30mg and Priligy 60 mg. The dosage prescribed depends on how well the patient responds and tolerates the treatment.

Recommended Dosage

  • Most men start with Priligy 30mg, taken before anticipated sexual activity.

  • If the 30 mg dose is well-tolerated but not sufficiently effective, the dose may be increased to Priligy 60 mg, as advised by a healthcare provider.

How to Take Priligy Tablets

  • Swallow the tablet whole with a full glass of water.

  • Do not chew, crush, or split the tablet.

  • It can be taken with or without food.

Timing

  • Take Priligy 1 to 3 hours before sexual activity for best results.

Frequency

  • Do not take more than one tablet within a 24-hour period.

  • It is not intended for daily or continuous use.

Missed Dose

  • Since Priligy is taken as needed, there is no concern about missing a scheduled dose.

Overdose Warning

  • Taking more than the recommended dose can increase the risk of side effects such as fainting, dizziness, or abnormal heart rhythm.

  • Seek immediate medical attention if an overdose is suspected.

Note: Priligy is a prescription medication. Do not self-adjust your dose without consulting a healthcare provider.

Strengths & Substitutes

Priligy comes in two strengths, giving patients flexibility based on their condition and doctor’s recommendation.

Available Strengths of Priligy Tablets


Strength

Form

Common Usage

Priligy 30mg

Oral tablet

Starting dose for most patients

Priligy 60 mg

Oral tablet

For those who need stronger effect and tolerate 30 mg well

Both strengths contain the same active ingredient — Dapoxetine Hydrochloride — and are used to treat premature ejaculation with similar timing and instructions.

Generic Priligy Options

Generic Priligy refers to medicines made by other manufacturers using the same active molecule, Dapoxetine. These versions are:

  • Clinically equivalent in safety, strength, quality, and performance

  • Often more affordable than the brand-name version

  • Available in the same 30mg and 60 mg strengths

Common generic alternatives to Priligy include:

  • Duratia

  • Duralast

  • Poxet

These generic Priligy tablets can be purchased from licensed pharmacies and are considered a reliable and cost-effective option. Patients can also buy generic Priligy online through reputable, approved platforms.

Always consult a doctor to determine whether to use branded Priligy tablets or a generic Priligy version based on medical history, affordability, and individual response.

Side Effects

Like all prescription medicines, Priligy tablets may cause some side effects. However, most are mild, temporary, and occur in the early days of use. Understanding the potential side effects can help you use Priligy pills more safely and confidently.

Common Side Effects

These are usually mild and may subside with continued use:

  • Nausea (most commonly reported)

  • Dizziness or light-headedness

  • Headache

  • Insomnia (difficulty sleeping)

  • Dry mouth

  • Fatigue

Tip: Taking Priligy tablets with food and staying well-hydrated may help reduce nausea and dizziness.

Less Common but Serious Side Effects

These may occur in some individuals and require medical attention:

  • Fainting or sudden drop in blood pressure

  • Blurred vision

  • Mood swings, irritability, or anxiety

  • Palpitations or increased heart rate

Severe Reactions (Seek Immediate Medical Help)

Although rare, some side effects may indicate a serious condition:

  • Seizures

  • Serotonin syndrome (symptoms: agitation, confusion, muscle twitching, fever)

  • Severe allergic reactions (swelling of the face, lips, or throat, difficulty breathing)

  • Loss of consciousness or blackouts

Important: These side effects are more likely in users who take more than the recommended dose or combine Priligy dapoxetine with alcohol, recreational drugs, or interacting medications.

If any symptoms feel unusual, intense, or persistent, contact a healthcare provider immediately.

Safety & Precautions

Before you buy Priligy or begin using Priligy pills, it’s important to understand who can safely take this medication and what precautions should be followed.

Who Should Avoid Priligy?

Do not use Priligy if you:

  • Have a history of heart problems, including arrhythmia, heart failure, or AV block

  • Have moderate to severe liver disease

  • Have a history of fainting or low blood pressure

  • Are currently taking MAOIs, SSRIs, SNRIs, tricyclic antidepressants, or thioridazine

  • Are allergic to Dapoxetine or any component of the formulation

  • Are over 65 years of age, unless advised by a specialist

Drug Interactions to Avoid

Do not take Priligy together with:

  • Nitrates (used for chest pain)

  • Alpha-blockers (used for high blood pressure or prostate enlargement)

  • CNS depressants or sedatives

  • Antifungal medicines like ketoconazole

  • HIV protease inhibitors

  • Other antidepressants or serotonin-enhancing medications

Combining Priligy with these drugs may lead to dangerously low blood pressure, serotonin toxicity, or fainting episodes.

Food & Lifestyle Considerations

  • Avoid alcohol: Drinking alcohol while on Priligy increases the risk of dizziness, fainting, and impaired judgment.

  • Do not drive or operate heavy machinery after taking Priligy, especially if you feel light-headed or drowsy.

  • Stay well hydrated and avoid skipping meals before taking the medication.

Special Warnings

  • Use caution if you have a history of mental health conditions such as depression, bipolar disorder, or seizures.

  • Not recommended for adolescents or men under 18 years of age.

  • Always inform your doctor about any medications or supplements you are taking before starting Priligy.

By understanding and following these safety precautions, users can reduce the chances of experiencing priligy side effects and ensure the medicine works effectively.

Clinical Trials & Approvals

Priligy, containing Dapoxetine, is the first oral treatment specifically approved for premature ejaculation (PE). Its clinical safety and efficacy have been extensively studied across multiple global trials.

Key Clinical Studies and Results

  • Global Andrology Forum Clinical Guidelines (2024)

    A meta-analysis of international studies concluded that Priligy significantly increased Intravaginal Ejaculation Latency Time (IELT) and improved sexual satisfaction. Side effects were mostly mild and temporary.

  • Randomized Controlled Trial: Dapoxetine + Sildenafil for Non-Responders

    A study published in the Al-Azhar International Medical Journal showed that combining Priligy with Sildenafil enhanced treatment outcomes in men who didn’t respond to Dapoxetine alone.

    Results:

    • IELT increased by over 2.5 times

    • 72% of men reported better sexual performance

    • Mild side effects were reported but manageable

  • Tryptophan Metabolism & Response to Dapoxetine (PubMed - PMID: 38511846)

    This study linked tryptophan metabolism with how well men respond to Priligy dapoxetine, suggesting that nutritional status can influence drug performance.

  • Regulatory Approvals

    Priligy is approved in over 60 countries, including:

    • India

    • Germany

    • France

    • Italy

    • Spain

    • South Korea

    • Mexico

    • Singapore

      It is available in both branded and generic Priligy forms in select regions, depending on market regulations.

Though not FDA-approved in the United States, Priligy remains one of the most clinically validated PE treatments available globally.

Patient Guidelines – Storage & General Use

To ensure Priligy remains effective and safe, follow these storage and usage instructions carefully.

Storage Instructions

  • Store at room temperature: 20°C to 25°C (68°F to 77°F)

  • Keep the medication in its original packaging

  • Avoid exposure to moisture, heat, or direct sunlight

  • Do not refrigerate or freeze the tablets

General Usage Guidelines

  • Keep out of reach of children and pets

  • Do not share this medication with others, even if they have similar symptoms

  • Do not take Priligy pills after the expiration date mentioned on the packaging

  • Always follow the exact dosage prescribed by your doctor

  • If you experience any side effects or have concerns, seek medical advice immediately

Disclaimer

This content is for informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare provider before starting or changing any medication, including Priligy.

References

  1. Taymour Mostafa et al. Global Andrology Forum Clinical Practice Guidelines on the Management of Premature Ejaculation. World Journal of Men’s Health. February 2025. [Accessed 25 April 2025]. Click here
  2. Ahmed Galal Shaaban Ramadan et al. Efficacy of Adding Sildenafil to Dapoxetine in Treatment of Dapoxetine Non-Responding Mono-Symptomatic Premature Ejaculation. Al-Azhar International Medical Journal. 2024. [Accessed 25 April 2025]. Click here
  3. Zhang Y, Wang Y, Liu Y, et al. Correlation between serum tryptophan metabolism and treatment efficacy of dapoxetine in patients with premature ejaculation. PubMed. PMID: 38511846. [Accessed 25 April 2025]. Click here
  4. DrugBank Online. Dapoxetine – Drug Summary. [Accessed 25 April 2025]. Click here
  5. Drugs.com. Dapoxetine (International Listings). [Accessed 25 April 2025]. Click here
  6. Drugs.com. Priligy (dapoxetine): What is it and is it FDA approved? [Accessed 25 April 2025]. Click here
  7. McCarty E, Dinsmore W. Dapoxetine: An Evidence-Based Review of its Effectiveness in Treatment of Premature Ejaculation. Core Evidence. 2012;7:1–14. [Accessed 25 April 2025] Click here
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