Glynase XL 10 Mg Tablets

Description

Glynase XL 10 Mg Tablets

Glynase XL 10 Mg Tablets contain glipizide 10 mg in an extended-release (XL) formulation. This higher-strength dose of the second-generation sulphonylurea glipizide is used in adults with type 2 diabetes mellitus whose blood glucose is not adequately controlled on the 5 mg dose or on other oral antidiabetics. The extended-release design maintains therapeutic glipizide levels across 24 hours, supporting once-daily dosing and reducing glycaemic variability.

Composition

About the Manufacturer

Glynase XL is manufactured by USV Private Limited, an Indian pharmaceutical company headquartered in Mumbai with expertise in diabetes, cardiovascular, and metabolic medicines. USV supplies medicines to regulated and emerging markets worldwide.

Mechanism of Action

Glipizide stimulates pancreatic beta cells to secrete insulin by binding to and closing the sulphonylurea receptor (SUR1) of ATP-sensitive potassium channels. Channel closure leads to membrane depolarisation, calcium influx via voltage-gated calcium channels, and insulin exocytosis. The resulting rise in circulating insulin lowers blood glucose both by enhancing peripheral glucose uptake and by suppressing hepatic glucose output. These effects are dependent on functioning pancreatic beta cells.

Indications

• Type 2 diabetes mellitus in adults, as an adjunct to diet and exercise
• Patients inadequately controlled on lower doses of glipizide or other sulphonylureas
• Used alone or in combination with metformin, DPP-4 inhibitors, or insulin

Dosage & Administration

• Swallow tablets whole with water; do not crush, chew, or split
• Take once daily with breakfast (the first main meal of the day)
• Usual dose: 10–20 mg once daily; maximum recommended dose 20 mg once daily
• Blood glucose and HbA1c should be monitored regularly to guide dose adjustments
• Use the lowest effective dose that achieves the target glycaemic control

Special Populations

• Elderly: More vulnerable to hypoglycaemia; use the lowest effective dose and monitor frequently
• Renal impairment: Increased risk of prolonged hypoglycaemia; use with caution and monitor closely
• Hepatic impairment: May reduce gluconeogenesis and drug metabolism; use with caution
• Children: Not indicated in paediatric type 2 diabetes
• Pregnancy: Not recommended; insulin is the preferred agent in pregnancy

Precautions

• Hypoglycaemia: most common side effect; risk is higher with irregular meals, excessive exercise, alcohol, and in elderly or renally impaired patients
• Patients should not skip meals; meal timing consistency is essential for safe use of sulphonylureas
• Secondary failure: response may decline over time as beta-cell function decreases; reassess therapy periodically
• Beta-blockers may mask tachycardia of hypoglycaemia; monitor blood glucose more closely in patients on beta-blockers

Contraindications

• Hypersensitivity to glipizide, other sulphonylureas, or any excipient
• Type 1 diabetes mellitus or diabetic ketoacidosis
• Severe renal or hepatic impairment
• Pregnancy and breastfeeding

Side Effects

• Very common: Hypoglycaemia
• Common: Weight gain, nausea, dizziness, diarrhoea, constipation
• Less common: Elevated liver enzymes, skin rash, pruritus
• Rare: Haemolytic anaemia, agranulocytosis, thrombocytopenia, hyponatraemia

Drug Interactions

• Fluconazole, NSAIDs, sulphonamides, warfarin: May enhance glucose-lowering effect; monitor closely
• Rifampicin, phenytoin, corticosteroids, thiazide diuretics: May reduce glycaemic control
• Beta-blockers: May mask signs of hypoglycaemia; blood glucose monitoring especially important
• Alcohol: Potentiates hypoglycaemia; advise taking alcohol with food and in moderation
• Metformin, DPP-4 inhibitors: Additive glucose-lowering; monitor for hypoglycaemia

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiry date printed on the pack.

Related Products

• Glynase XL 5 Mg Tablets – lower-strength glipizide XL for initiation
• Glycomet SR 500 Mg Tablets – metformin sustained-release for combination therapy
• Huminsulin 70/30 100 IU – premixed human insulin for advanced diabetes management

Frequently Asked Questions

What is Glynase XL 10 Mg used for?

Glynase XL 10 Mg is an oral medicine used to lower blood sugar in adults with type 2 diabetes. It works by prompting the pancreas to release more insulin. It is prescribed when diet, exercise, and lower doses of antidiabetic medicines have not achieved adequate blood sugar control.

Can I take Glynase XL 10 Mg twice a day?

Glynase XL 10 Mg is an extended-release tablet designed for once-daily dosing. Taking it more frequently than prescribed would increase the risk of hypoglycaemia. Always take it exactly as your doctor has prescribed — once daily with breakfast.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember — but only if it is still the same day and you have not yet eaten your next main meal. If it is already close to the time of your next dose, skip the missed dose and resume your normal schedule. Never double the dose.

Why am I gaining weight on Glynase XL?

Sulphonylureas including glipizide stimulate insulin secretion, and insulin is an anabolic hormone that promotes fat storage. Weight gain is a common and expected side effect of sulphonylurea therapy. Regular exercise, portion control, and dietary advice from a dietitian can help manage this. Discuss alternative agents with your doctor if weight gain is a significant concern.

How is Glynase XL different from other diabetes tablets like metformin?

Glipizide (Glynase XL) works by directly stimulating the pancreas to produce more insulin, so it lowers blood sugar quickly. Metformin, by contrast, primarily reduces the liver’s production of glucose and improves insulin sensitivity, without directly stimulating insulin secretion, and therefore rarely causes hypoglycaemia on its own. The two are commonly combined because they work by complementary mechanisms.

References

1. NHS – Glipizide
2. MedlinePlus – Glipizide
3. FDA – Glipizide Extended-Release Prescribing Information
4. EMA – Glipizide-Containing Medicinal Products Assessment

Disclaimer: This page is for informational purposes only and does not constitute medical advice. Glynase XL 10 Mg Tablets should be prescribed and monitored by a qualified healthcare professional. Regular blood glucose and HbA1c monitoring is essential for safe and effective diabetes management.