Brand Name | Imat 400mg |
Packaging Type | Strip |
Molecule | Imatinib |
Generic Name | Imatinib 400mg |
Manufactured By | Zydus oncosciences |
Quantity | 10 Tablets |
Form | Tablet |
Country of Origin | India |
Categories | Blood Cancer |
Introduction to Imat Imatinib 400mg Tablet
How Imatinib Tablet Works?
Uses of Imat Imatinib 400mg Tablets
- Imatinib blocks the BCR-ABL tyrosine kinase enzyme, which is responsible for cancer cell growth in CML.
- Specifically effective for Philadelphia chromosome-positive (Ph+) ALL, a subtype of leukemia. It interrupts the signaling pathways that promote the uncontrolled growth of cancer cells.
- Imatinib inhibits the proteins responsible for tumor growth, slowing or stopping its progression.
- It targets and regulates genetic abnormalities causing these disorders.
- Imatinib helps normalize eosinophil levels by targeting abnormal signaling pathways.
- It blocks PDGF receptor pathways involved in tumor growth, preventing further progression.
Dosage and Administration
- The recommended dose for most conditions is 400mg once daily. In some cases, the dose may be increased to 600mg or 800mg daily based on the patient’s response and medical condition.
- Swallow the tablet whole with a glass of water. Take it with food to reduce the risk of stomach upset.
- If you forget to take a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose and continue as scheduled. Do not double the dose.
- Continue taking the medication as advised by your doctor. Do not stop treatment unless instructed by your healthcare provider.
Side Effects of Imat Imatinib 400mg Tablets
Common Side Effects
- Swelling
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Muscle cramps
- Fatigue
- Dizziness
- Skin rash
- Increased weight
- Decreased red or white blood cell counts
Serious Side Effects
- Liver problems
- Heart issues
- Gastrointestinal bleeding
- Low blood cell counts lead to anemia
- If you experience severe side effects, such as difficulty breathing, chest pain, or symptoms of liver issues, contact your doctor immediately
Precautions and Warnings
Drug Interactions
- Antibiotics
- Antifungal medications
- Blood thinners
- Medications for seizures
- Herbal supplements
Criteria | Imat Imatinib 400mg Tablet | Gleevec Imatinib 400mg Tablet |
Active Ingredients | Imatinib | Imatinib |
Manufacturer | Zydus Oncoscience | Novartis |
Primary use | Treatment of CML, GST, and other cancer | Treatment of CML, GST, and other cancer |
Key difference | Generic version of Gleevec, typically more affordable | Branded often, more expensive |
Side effect | Fatigue, nausea, edema etc | Same as generic, including heart failure, liver issues |
Cost | $75 (apx) | $30(apx) |
Imat 400mg Tablets is used in the treatment of blood cancer. It works by decreasing the number of red blood cells, which is produced by the body. Thereby prevents the cancer cells from growing and multiplying. Imat 400mg Tablets interfere with the growth of cancer cells and can reduce immune system activity.
When taking Imat 400mg Tablets, avoid grapefruit and Seville oranges because they can interfere with how the medication works. Limit high-fiber foods, like raw meats, eggs, and seafood, to reduce digestive risks and infections, which can be more challenging with Imat 400mg Tablets. Use alcohol sparingly or avoid it completely to prevent interactions that might affect treatment.
After taking Imat 400mg Tablets generally, some patients may begin to see initial effects within a few weeks of starting treatment, such as a reduction in symptoms or stabilization of blood counts. It can take between 6 - 12 weeks before you start to feel the benefits of your treatment. However, to fully assess its effectiveness in controlling cancer growth and achieving remission, it typically requires several months of continuous treatment. 6-MP Mercaptopurine does not work immediately.
Nausea and vomiting Loss of appetite Diarrhea Mouth sores Fatigue
Always talk to your doctor before taking Imatinib 400mg with other medications. This is important because Imatinib 400mg can interact with other drugs, which might change how it works or increase the risk of side effects. Your doctor can help you safely manage all your medications together.