Osimert 80mg - Generic Tagrisso

Overview of Osimert 80mg

Osimert 80mg, manufactured by Everest Pharmaceuticals, is a popular prescription medicine for treating non-small cell lung cancer (NSCLC). This medicine's active ingredient is Osimertinib and it functions by blocking the EGFR protein, the main source of growth in cancer cells. By blocking this protein, Osimertinib helps to slow tumour progression and alleviate symptoms such as coughing and difficulty breathing.

Osimert 80mg is typically taken as a single, whole tablet once a day. One of its key advantages is that it tends to cause fewer side effects compared to traditional chemotherapy treatments. Proper medical supervision is necessary before taking this medicine. 

Key Benefits of Osimert 80

Here are some common distinguishing benefits of Osimert 80mg:

• Osimert 80mg particularly targets EGFR mutations that are responsible for the growth of cancer cells. This kind of focused intervention disrupts the process and hinders cancer progression at its core. 

• Osimert 80mg is especially beneficial for patients who have developed resistance to first-generation EGFR inhibitors. This medicine is not only used as an effective treatment option but also serves as a line of defence against cancer.

• As per the clinical evidence, it is suggested that Osimert 80mg by Everest Pharma significantly contributes to progression-free survival in patients with advanced NSCLC. By slowing tumour growth, it offers hope for extending life and alleviating disease progression, improving patients' overall prognosis.

• Unlike traditional chemotherapy, Osimert 80mg primarily targets cancer cells, minimizing harm to healthy, normal cells. This selective action reduces side effects and helps enhance the body’s tolerance to the medication, making the treatment more manageable for patients.

How Does Osimert 80 Work?

Osimert 80mg, commonly known as Tagrisso Generic, is a powerful medicine for treating lung cancer. It works well by blocking the EGFR protein, which is the root cause for cancer cells to grow. This protein component keeps on changing among lung cancer patients and thus the disease becomes difficult and challenging to cure. In many lung cancer patients, the EGFR protein undergoes mutations, which allow cancer cells to grow uncontrollably. 

It also lowers the growth of tumours, improving breathing and coughing over time. Before taking this medicine, patients should follow doctors' instructions carefully. 

For individuals with pre-existing lung or heart conditions, it is crucial to monitor these aspects regularly while using Osimert 80mg, as the medication may have some impact on these organs. When used correctly, Osimert 80mg can provide significant relief and improve the quality of life for patients, helping them manage the disease and live longer.

Dosage and Administration of Osimert 80

Here is how Osimert should be administered:

• The recommended dosage of Osimert 80mg by Everest Pharma is once daily until disease progression occurs or if unacceptable toxicity is observed. 

• Individuals can take this medicine both with or without food. 

• If you miss any dosage of Osimertinib, do not go for the missed dose, instead take up the next dose as scheduled. 

• If there is difficulty in swallowing solids, the Osimert 80mg tablet should be dissolved into 4 tablespoons of noncarbonated water only. Continue stirring until it gets dispersed completely and then swallow it through a nasogastric tube immediately. 

• Make sure not to heat, crush or ultrasonicate during preparation. 

Strengths and Substitutes of Osimert 80

Osimert 80mg helps to treat non-small cell lung cancer (NSCLC) with EGFR mutations. It primarily targets cancer cells, slows tumour growth, and enhances patient survival rates. It has fewer side effects than traditional chemotherapy, making it suitable and convenient for patients.  There is only one strength of Osimert, which is 80mg. 

The most popular substitute for Osimert 80mg is Tagrisso 80mg. Both medications contain the same active ingredients, but Tagrisso is a popular brand name manufactured by AstraZeneca. However, there are quite a few more substitute medications available: 

• Tagrisso Osimertinib 80mg Tablets

• Ositab 80mg Tablet

• Irmukin 80mg Tablets 

• Tasso 80mg Tablets

• Osimatab 80mg Tablet

• Tagrix Osimertinib 80mg Tablets

• Osikin 80mg Tablets

• Osicent Osimertinib 80mg Tablets

• Osinib 80mg Tablets

• Tasso 80mg Tablets

• Osmigen 80mg Tablets

Side Effects of Osimert 80

Some of the common side effects of Osimert 80mg include the following:

• Diarrhea

• Tired feeling

• Loss of appetite

• Mouth sores

• Dry skin

• Rash

• Discolouration

• Pain

• Infection

• Problems with fingernails or toenails

Some other more serious side effects include:

• Shortness of breath with mild exertion

• The feeling of light-headed, likely you might pass out

• Fast heartbeat

• Swelling

• Fast weight gain

• Worsening of lung symptoms such as discomfort, chest pain, dry cough, wheezing, shortness of breath and others

• Eye problems – changes in vision, watery eyes, eye pain, redness, increased sensitivity to light

Safety and Precautions of Osimert 80

Osimert 80 is one of the popular and targeted treatments used for treating non-small cell lung cancer (NSCLC) with specific genetic mutations. With its effectiveness, it needs close monitoring because of its potential side effects.

Patients should follow the medical guidance and undergo check-ups on a regular basis to ensure safety. Let us explore the safety and precautions of Osimert 80 in detail below:

• Interstitial Lung Disease (ILD): Commonly known as pneumonia, patients diagnosed with this disease should permanently discontinue this medicine.

• Cardiomyopathy: Before starting Osimert 80mg, a patient’s left ventricular ejection fraction (LVEF) should be assessed. Regular monitoring of LVEF should continue every 3 months during treatment to detect any potential signs of cardiomyopathy.

• QTc Interval Prolongation: Patients with a history of QTc prolongation or those who take medicines for prolonging the QTc interval, should keep daily monitoring of electrolytes and electrocardiograms. If significant QTc prolongation is observed, Osimert 80mg may need to be withheld and later reintroduced at a reduced dose, or it may need to be permanently discontinued.

• Keratitis: Patients should inform their healthcare provider immediately if they are suffering from this eye disease and have symptoms such as lacrimation, eye inflammation, pain in eyes, light sensitivity, redness in eyes and changes in vision. 

• Embryo Fetal Toxicity: Osimert 80mg can cause significant harm to a developing fetus, making it unsafe for pregnant women. Females of childbearing potential should use effective contraception during treatment with Osimert and continue for 6 weeks after the last dose. On the other hand, males should use effective contraception for 4 months after the final dose to prevent potential exposure to the drug through semen.

Consult with your doctor to see if Osimert 80mg is suitable for you. Make sure to follow the medical advice carefully and do not start consuming the medicine without consultation from a healthcare professional. 

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC11315406/

https://pmc.ncbi.nlm.nih.gov/articles/PMC6516134/

https://www.researchgate.net/publication/381124538_Phase_II_Efficacy_and_Safety_of_80_mg_Osimertinib_in_Patients_With_Leptomeningeal_Metastases_Associated_With_Epidermal_Growth_Factor_Receptor_Mutation-Positive_Non-Small_Cell_Lung_Cancer_BLOSSOM

https://www.everestpharmabd.com/public/images/attach_file/attach_file_1018641518019561.pdf