| Brand Name | Osimert |
| Packaging Type | Bottle |
| Molecule | Osimertinib |
| Generic Name | Osimertinib 80mg |
| Manufactured By | Everest Pharmaceuticals |
| Quantity | 30 Tablets |
| Form | Tablets |
| Country of Origin | Bangladesh |
| Categories | Oncology |
Introduction To Osimertinib 80mg Tablets
Osimert 80 mg is the generic version of Tagrisso 80 mg, originally manufactured by AstraZeneca India, while Osimert 80 mg is manufactured by Everest Pharmaceuticals. The active ingredient, Osimertinib, is a medicine used to treat non-small cell lung cancer (NSCLC) in patients with abnormal changes in the epidermal growth factor receptor (EGFR).
This medication is prescribed for adults with NSCLC after surgery to remove tumors in stage IB-IIIA. It is also used to treat metastatic NSCLC (cancer that has spread) in patients who did not respond well to previous treatments with EGFR tyrosine kinase inhibitors (TKIs).
Osimertinib belongs to a group of medicines called EGFR tyrosine kinase inhibitors. On April 18, 2018, the U.S. Food and Drug Administration (FDA) approved it as a first-line treatment for patients with NSCLC, showing its ability to improve patient outcomes.
Osimert 80mg- Uses
Osimert Osimertinib 80mg medicine is used to treat certain types of EGFR-positive NSCLC:
- Osimertinib works as an adjuvant therapy.
- This medication is sometimes given when the cancer has spread to other parts of the body (metastatic), or may come back after surgery.
- Osimert 80 is an initial treatment option for metastatic cancer.
Full prescription information for Osimertinib is posted Here
Drug Classes :
Cytotoxic Chemotherapy
Pharmacology
Osimertinib is a type of medicine called a kinase inhibitor that targets the epidermal growth factor receptor (EGFR). It sticks to certain mutated forms of EGFR (like T790M, L858R, and exon 19 deletion) much more easily than normal EGFR. In lab tests with cells and animals, Osimertinib showed strong effects against non-small cell lung cancer (NSCLC) with these mutations and had weaker effects on normal EGFR.
After taking Osimertinib, two similar active substances (called AZ7550 and AZ5104) were found in the blood. AZ7550 worked about the same as Osimertinib, while AZ5104 was much stronger against some EGFR mutations, including exon 19 deletion and T790M.
Osimertinib can also block other proteins, like HER2, HER3, HER4, ACK1, and BLK, which are involved in cancer growth, at doses that work in the body.
Osimertinib: Simple Overview of its Chemical Structure
Osimertinib is a type of medication known as a kinase inhibitor, which is taken by mouth. The molecular formula for Osimertinib is C28H33N7O2•CH4O3S, and the weight of the molecule is 596 g/mol. There is a specific arrangement of atoms in the drug, which includes components such as a pyrimidine ring, an indole ring, and a methyl group. Such structures provide Osimertinib its potential to stop and attack cancer-related cells in the patient's body.
How does Osimert Osimertinib 80mg work
Osimert Osimertinib 80mg Tablet is an anti-cancer drug that works by inhibiting the action of abnormal or cancerous proteins that are responsible for the growth and multiplication of cancer cells. This helps to stop and slow down the spread of cancer cells.
Osimertinib- Dosage
The Osimert 80mg tablet can be taken with or without food, it is best to take this medicine at the same time for the best and most beneficial results. Take Tagrisso lung cancer medicine in the dose and duration as advised by your doctor. It may take a few weeks or months to notice the benefits, so taking it properly in the recommended amount as prescribed gives the best result.
Osimertinib- Administration
For Patients who find it difficult to swallow whole tablets or solid tablets, dissolve the Osimert tablet in 60ml of non-carbonated water. Stir the drug into small pieces, Osimert tablet will not fully dissolve, and consume it immediately. Do not heat and crush the tablet. If administering the medication through a nasogastric tube, mix the tablets in 15 ml of non-carbonated water. Then use another 15 ml of water to rinse any remaining part into the syringe.
Osimert 80 Mechanism of Action
Osimert 80mg is a medicine that is targeted therapy designed to address specific mutations in the EGFR. This drug works by binding to these mutant forms of EGFR, which helps to stop mutations such as T790M and L858R. Osimert medication affects other related proteins that play a role in tumor growth.
What if you forget to take this tablet?
If you miss a dose of Generic Tagrisso 80mg, just skip it & take your next dose as usual. Do not double the dose.
Who should use these tablets?
Here are the specific patient groups who should use Osimertinib:
- EGFR Mutation-Positive Patients
- Patients with Metastatic non-small cell lung cancer (NSCLC)
- First-line treatment for patients with metastatic NSCLC
- Patients Who Have moved on Prior EGFR Therapy
- Patients look for a Targeted Therapy Option
- Patients Needing Medication with central nervous system (CNS) Penetration
Benefits of Osimert Osimertinib Tablet
Non-small cell lung cancer affects smokers and non-smokers. Osimertinib tablets treat this condition and may be prescribed alongside other medications. It is a toxic and powerful drug, so it's essential to discuss risks and benefits with a doctor.
Osimertinib Side Effects
Some common side effects of this medication are:
- Dry skin
- Low white blood cell counts
- Low platelet counts
- Anemia
- Diarrhea
- Rash
- Mouth sores
- Loss of appetite
- Inflammation of the mouth
- Changes in patients nail
- Joint and muscle pain
- Cough
- Tiredness
Osimert 80ng may cause serious side effects, including:
- Vision change & eye redness or pain
- Blisters on the soles of your feet or palms
- Fast heart beats
- Weight gain
- Shortness of breath
- Swelling in lower legs
- Respiratory problems: Osimert Osimertinib may cause serious lung issues that could lead to death. It is important to tell a patient's healthcare specialist immediately if a patient is experiencing any new lung symptoms or trouble breathing, fever, or cough.
- Cardiac Problems: This medicine may cause heart problems. Patient doctors need to evaluate heart function before initiating treatment with these tablets. If the Patient is experiencing a pounding heartbeat, difficulty breathing, and dizziness, tell the patient's doctor immediately.
- Skin problem: Osimert 80mg medication has the potential to cause dermatological issues, this can cause skin reactions resembling ring-shaped lesions.
- Skin blood vessel inflammation: This medication may cause blood vessels problems in patients skin. Symptoms like purple spots redness of the skin, or redness on the patient's lower arms, legs, or buttocks can occur.
Inform the Patient’s Healthcare Provider About These Conditions Before Taking Osimertinib.
- If patients have cardiac issues, including long OTc syndrome.
- If a patient is suffering from respiratory issues aside from lung cancer.
- Have a prior history of eye-related issues.
- If a patient experiencing a problem with electrolytes, like magnesium, sodium, potassium, or calcium.
- If a patient is pregnant or intends to become pregnant.
Precautions to Consider Before Taking Osimertinib.
Consult with a doctor to know whether Osimertinib is safe to consume alcohol while taking Osimert 80mg.
Osimertinib may pose risks during pregnancy, it is crucial not to take this if patients are pregnant, or planning to become pregnant. Animal research studies have shown harmful effects on the developing baby. 
The use of Osimert 80 mg during breastfeeding is likely unsafe, as limited evidence suggests that the drug can transfer into breast milk and potentially harm the infant.
Osimertinib medication does not affect driving ability
It is safe to use in patients with kidney disease.
It is also safe for patients with liver disease without any dose adjustment of Osimert is recommended. 
Regularly monitor a patient's blood pressure while consuming Osimertinib. Consult or inform patient healthcare providers if they notice symptoms indicative of very high BP.
Why Choose Osicent Osimertinib 80mg?
Osimert Osimertinib 80 mg Tablets is a low-cost generic alternative to Tagrisso, offering the same effects at a more affordable price and is also known as Generic Tagrisso. It provides the same therapeutic benefits, quality standards, and safety. Tagrisso's cost is generally higher but Osimertinib 80mg price is cheaper.
Osimertinib (Generic) vs. Tagrisso (Brand)
| Feature | Osimertinib (Generic) | Tagrisso (Brand) |
| Active Ingredient | Osimertinib | Osimertinib |
| Manufacturer | Various manufacturers | AstraZeneca |
| Dosage Forms | 80mg tablets | 80mg tablets |
| Dosage Forms | Metastatic EGFR T790M mutation-positive NSCLC | Metastatic EGFR T790M mutation-positive NSCLC |
| Efficacy | Equivalent to Tagrisso | Proven in clinical trials |
| Price | Osimertinib price is Generally lower in cost | Tagrisso price is Higher |
| Approval Status | Approved in several countries as a generic alternative | FDA and EMA approved |
| Regulatory Standards | Must meet generic drug approval standards (bioequivalence) | Approved based on original clinical trials |
How to store Osimert Osimertinib80mg ?
Store this medication below 30°C, and avoid light. Keep out of reach of children
No, Osimertinib is not a traditional chemotherapy drug. It is a targeted therapy that specifically inhibits EGFR mutations involved in the growth and spread of non-small cell lung cancer (NSCLC).
Osimertinib 80 mg is used to treat non-small cell lung cancer (NSCLC) with specific EGFR mutations.
Common side effects of Osimertinib 80 mg include diarrhea, rash, dry skin, nail toxicity, and fatigue.
Tagrisso targets non-small cell lung cancer (NSCLC) with specific EGFR mutations.
Yes, Tagrisso has been shown to be effective in treating stage 4 non-small cell lung cancer with specific EGFR mutations, prolonging survival and delaying disease progression.
Tagrisso works by inhibiting the activity of mutated EGFR, which is responsible for the growth of certain types of non-small cell lung cancer. By blocking this pathway, the drug prevents cancer cells from growing and spreading.
The life expectancy of a patient taking Osimertinib depends on various factors, including the stage of cancer, individual response, and overall health. Clinical studies show that it can significantly extend life expectancy in patients with advanced NSCLC.
The cost of Osimertinib 80 mg in the US varies but is generally very expensive, often running into several thousand dollars per month without insurance coverage.
Yes, Tagrisso works by targeting and killing cancer cells that have specific EGFR mutations, inhibiting their growth and spread in non-small cell lung cancer (NSCLC).
If you miss a dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at once to make up for the missed dose.
Osimertinib is usually taken once a day, with or without food. If you have difficulty swallowing the tablet, you can place it in a glass with about 2 ounces of water, stir until the tablet is mostly dissolved, and drink the mixture immediately.
Yes, Tagrisso can interact with several drugs, including antiarrhythmics, antipsychotics, antibiotics, and supplements like St. John’s wort. These interactions may increase the risk of side effects or make Tagrisso less effective.
Yes, Tagrisso may reduce fertility in both males and females. If you're concerned about future fertility, talk to your doctor about options like sperm or egg preservation.
No, Tagrisso is not safe during pregnancy or breastfeeding. Use birth control while taking Tagrisso and for several weeks after your last dose.
You can order Osimertinib by logging into your account on our website, adding the tablet to your cart, and proceeding to checkout. After successful payment, your order will be confirmed, and you will receive a confirmation email. You can also contact us via WhatsApp to place your order directly.
It is recommended to avoid grapefruit and grapefruit juice while taking Tagrisso, as these can interfere with the medication's effectiveness.
Alternatives to Osimertinib include other EGFR inhibitors such as Erlotinib (Tarceva), Gefitinib (Iressa), and Afatinib (Gilotrif).
No, Osimertinib (Tagrisso) is a prescription medication, and you need a doctor’s prescription to obtain it.
