| Brand Name | Tagrisso-80mg |
| Packaging Type | Strip |
| Molecule | Osimertinib |
| Generic Name | Osimertinib 80mg |
| Manufactured By | Astrazeneca |
| Quantity | 30 Tablets |
| Form | Tablet |
| Country of Origin | India |
| Categories | Oncology |
Overview of Tagrisso 80
Tagrisso 80mg is a prescription medicine containing Osimertinib, which is widely used to treat non-small cell lung cancer (NSCLC). It belongs to the tyrosine kinase inhibitor(TKI) class of medications and works well for patients with Epidermal Growth Factor Receptor (EGFR) mutation-positive NSCLC.
Tagrisso works by blocking abnormal EGFR activity, thereby slowing or stopping the growth of cancer cells. Manufactured by AstraZeneca, it has shown improvement in survival rates in patients with advanced lung cancer.
This is available only through prescription and should be consumed under medical supervision only.
Key Benefits of Tagrisso 80
Some of the key benefits of Tagrisso 80 (Osimertinib) are as follows:
Tagrisso mainly targets the epidermal growth factor receptor (EGFR) mutations, preferably among non-small cell lung cancer (NSCLC).
It remains effective even in cases where patients have developed resistance to earlier EGFR-targeted therapies, offering hope to patients with limited availability of treatment options.
Taking this medicine orally once daily helps prevent the spread of cancer further to the brain and other body parts, making it especially beneficial for patients with metastatic NSCLC.
When taken in the prescribed dosage, the drug is generally well-tolerated. Its side effects, including skin rash and diarrhoea, are manageable, making it a suitable long-term treatment option.
How Does Tagrisso 80 Work?
Tagrisso contains the active ingredient Osimertinib, a type of cancer treatment known as a tyrosine kinase inhibitor (TKI). It specifically targets certain proteins involved in the growth and spread of cancer cells, making it a highly effective option for treating specific types of lung cancer. This medicine further blocks the activity of EGFR, which further exerts control over the growth and division of cells.
In non-small cell lung cancer (NSCLC), EGFR mutations cause the receptor to become overactive, leading to uncontrolled cancer cell growth. Because of the distinguishing feature of inhibiting EGFR, Osimertinib can reduce growth and prevent further spreading of cancer.
Dosage and Administration of Tagrisso 80
The table below displays the recommended dosage of Tagrisso 80 in terms of indication:
Indicator | Dosage Recommended for Tagrisso | Treatment Duration |
Adjuvant Treatment of EGFR Mutation – Positive NSCLC | Take Tagrisso 80mg tablet orally once daily with or without food. | For 3 years or until the disease occurs again. |
First-Line Treatment of EGFR Mutation- Positive Metastatic NSCLC | Oral consumption of Tagrisso tablet 80mg daily with or without food | Until disease progression or unacceptable toxicity occurs. |
First-line Treatment of EGFR Mutation-Positive Locally Advanced or Metastatic NSCLC | Take one 80mg tablet orally once daily, with or without food, in combination with platinum-based chemotherapy. | Until disease progression or unacceptable toxicity occurs. |
Earlier Treated EGFR T790M Mutation – Positive Metastatic NSCLC | Consume 80mg tablet orally daily with or without food | Until disease progression or unacceptable toxicity occurs. |
Patients with difficulty of swallowing, or nasogastric tube administration can take this medicine as a whole with water. If any dose gets missed, do not worry about taking the missed dose. Instead, take the next scheduled dose.
Strengths and Substitutes of Tagrisso 80
Following is a detailed table of strengths and substitutes of the Tagrisso tablet:
Medication | Dosage | Appearance | Markings | Substitutes |
Tagrisso | 40mg | Oval, beige, biconvex | "AZ 40" on one side, plain on the other | No substitutes available |
Tagrisso | 80mg | Oval, beige, biconvex | "AZ 80" on one side, plain on the other | Keytruda, Opdivo |
Side Effects of Tagrisso 80
Similar to other medicines, Tagrisso 80 has also several side effects. Make sure to inform your healthcare provider if any side effects bother you for a prolonged period. Here is the list of the most common side effects of Tagrisso 80:
Diarrhoea
Blood disorders
Pain in muscles or bones
Rash
Dry skin
Changes in nail
Tiredness
Mouth sores
On the other hand, here are some most serious forms of side effects, while they may be less common. Let us look into those effects in detail below:
Allergic Reactions
Tagrisso 80 might cause severe allergic reactions. If any of the following symptoms occur, stop taking Tagrisso right away and consult your doctor:
Racing heart
Problems in breathing or wheezing
Swollen lymph nodes
Fever or a sudden ill feeling
Swelling of lips, mouth, face, throat and tongue
Trouble in swallowing or throat tightness
Nausea or vomiting
Skin rash, itching, or red bumps on the skin, commonly known as hives
Cramps in stomach
Joint pain
Dizziness, fainting, or light-headed
Changes in Heart Rhythm
Taking Tagrisso 80mg daily may affect heart rhythm, potentially causing irregular heartbeat, fainting, or, in rare cases, heart failure. Individuals with pre-existing heart conditions or those taking heart-related medications are at a higher risk. Seek medical help if you face any of the following signs of heart rhythm changes:
Shortness of breath
Chest pain
Lightheaded, dizzy, or fainting
Sudden changes in your heart rhythm which can be slow, fast, or skipping heartbeat
Issues in Eyes
Taking Tagrisso 80 can cause swelling in the eyes. Ask for medical help immediately if you face any of the following symptoms:
Watery eyes
Blurry vision
Pain in eyes
Sensitivity to light
Swelling or causing redness in eyes
Safety and Precautions of Tagrisso 80
Understanding Tagrisso 80’s safety and precautions is essential for proper usage and minimising risks. Let us explore the safety and precautions feature in detail below:
- Alcohol: Whether you should consume alcohol with Tagrisso 80mg tablet, consult your doctor immediately.
Breast Feeding: Do not take Tagrisso 80mg tablet during breastfeeding. As per several research, the drug might pass into the breastmilk and affect the baby’s health.
Pregnancy: Tagrisso 80mg is not safe for use during pregnancy, as it can cause harm to the developing baby. Your doctor will carefully evaluate the risks and benefits before prescribing this medication. If you are pregnant or planning to conceive, discuss alternative treatment options with your healthcare provider.
Kidney: Patients with kidney disorders can consume Tagrisso 80mg tablets and there is no need for adjustment of the medicine.
Driving: Usually, Tagrisso 80mg does not create a significant impact on your ability to drive.
Liver: Patients with liver disease can easily consume Tagrisso 80mg tablets. There is no need to adjust dosages.
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