Tadalafil vs Sildenafil: Know the Key Differences
When it comes to medications for erectile dysfunction (ED), you have probably heard of the "little blue pill" or Viagra- but did you know there are different options available? Two of the most common active ingredients are Tadalafil and Sildenafil, and while they both help with ED, they work in slightly different ways.
Erectile dysfunction affects millions of men worldwide and can be caused by various factors, including stress, certain health conditions, or simply ageing. Thankfully, medical science has developed effective treatments that have helped many men regain confidence and enjoy healthy intimate relationships.
This blog breaks down the comparison between Tadalafil vs Sildenafil in simple terms to help you understand their benefits, side effects, dosages, and more. Let us start by getting to know each of them a bit better.
Overview of Both Tadalafil and Sildenafil
Sildenafil is the active ingredient in Viagra, which was the first major ED medication to hit the market back in 1998. Sildenafil works for about 4-6 hours and is typically taken as needed before sexual activity.
Tadalafil is the active ingredient in Cialis, which was approved a few years after Viagra. It is sometimes called the "weekend pill" because its effects can last up to 36 hours. Tadalafil can be taken either as needed or as a daily medication in a smaller dose.
Both medications belong to a class of drugs called PDE5 inhibitors, but they have some important differences in how long they work and how quickly they start working.
How Do Tadalafil and Sildenafil Work?
To understand how these medications work, we need to know what happens naturally during an erection.
When a man is sexually aroused, his body releases a chemical called nitric oxide into the penis. This triggers another chemical called cGMP, which relaxes the blood vessels and allows more blood to flow in, which creates an erection.
However, there is another chemical PDE5, that breaks down cGMP. PDE5 can break down cGMP too quickly, making it difficult to get or maintain an erection.
Tadalafil and Sildenafil both target the PDE5 enzyme. By blocking this enzyme, these medications help:
Relax the blood vessels in the penis
Increase blood flow to erectile tissue
Make it easier to get and keep an erection
It is important to remember that neither medication automatically causes an erection. You still need sexual stimulation for them to work.
Sildenafil vs Tadalafil: Key Differences
While both medications work in similar ways, there are several important differences between them:
Duration of Action
Sildenafil: Works for about 4-6 hours
Tadalafil: Can work for up to 36 hours
This is perhaps the biggest difference between the two. Sildenafil is more of a "take it when you need it" medication, while Tadalafil's longer-lasting effects have earned it the nickname "the weekend pill". You can take it Friday night, and it could still be effective on Sunday morning.
Food Interactions
Sildenafil: Works best when taken on an empty stomach; high-fat meals can delay its effect.
Tadalafil: Can be taken with or without food; food does not significantly impact its effectiveness.
This makes Tadalafil more flexible for those who do not want to plan their meals around medication.
Dosing Options
Sildenafil: Usually taken as needed.
Tadalafil: Can be taken as needed or daily in a lower dose.
The daily dosing option for Tadalafil allows men to be ready for sexual activity anytime, eliminating the need for planning.
Onset of Action
Sildenafil: Typically begins working within 30-60 minutes.
Tadalafil: Usually begins working within 30-45 minutes, but can take up to 2 hours to reach full effect.
Sildenafil vs Tadalafil: How Much to Consume and When?
Getting the dosage right is important for both effectiveness and safety. Here is a breakdown of typical dosages:
Sildenafil:
Typical Starting Dose: 50mg
Dose Range: 25mg to 100mg
Usually taken 30-60 minutes before sexual activity
Should not be taken more than once per day
Works best when taken on an empty stomach
Your doctor might start you on a lower dose (25mg) if you are older or have certain health conditions, or might increase the dose to 100mg if 50mg is not effective enough.
Tadalafil:
For As-needed Use: Typical dose is 10mg, with a range of 5mg to 20mg
For Daily Use: Typical dose is 2.5mg or 5mg
As-needed dose should be taken at least 30 minutes before sexual activity
Daily dose is taken at the same time each day, regardless of sexual activity
Can be taken with or without food
The daily dosing option for Tadalafil can be particularly helpful for men who have frequent sexual activity (more than twice a week) or who prefer not to plan their intimate moments around medication. Here is how these medications should be administered:
Men with kidney or liver problems usually need lower doses of either medication.
Age is also a factor – men over 65 typically start at lower doses because their bodies may process the medications more slowly.
The right Tadalafil vs Sildenafil dosage depends on various factors including your health, other medications, and how your body responds.
Always follow your doctor's recommendations for the best results.
Side Effects of Sildenafil & Tadalafil: Which One is Safer?
Both medications are generally safe when used as prescribed, but like all medications, they can cause side effects. Most side effects are mild and temporary. Understanding the Tadalafil vs Sildenafil side effects can help you make an informed choice.
Common Side Effects of Both:
Headache
Flushing (redness and warmth in the face)
Indigestion or upset stomach
Nasal congestion
Dizziness
Back pain
Muscle aches
Unique to Sildenafil:
Visual changes (blue tinge to vision, increased light sensitivity)
These visual side effects are rare but more common with Sildenafil than with Tadalafil.
Unique to Tadalafil:
Because it stays in your system longer, side effects may last longer.
May cause limb pain more frequently than Sildenafil.
Serious Side Effects (Rare but Important to Know):
Priapism (an erection lasting more than 4 hours), which requires immediate medical attention
Sudden hearing loss
Sudden vision loss
Severe drop in blood pressure, especially when combined with certain other medications
In terms of safety profile, neither medication is clearly "safer" than the other. The better choice depends on your health situation and preferences. For example, if you have certain eye conditions, your doctor might recommend Tadalafil over Sildenafil due to the latter's potential visual side effects.
The intensity of side effects often relates to dosage, where higher doses tend to cause more noticeable effects. Some men find that side effects become less bothersome over time as their body adjusts to the medication.
Note: Always report any side effects to your doctor, even if they seem minor. Always remember, never adjust your dosage without consulting your healthcare provider.
Sildenafil vs Tadalafil: Which One Acts Faster
When it comes to speed of action, there is a slight difference between the two:
Sildenafil:
Typically begins working within 30-60 minutes
Peak effect usually occurs within 60-120 minutes
Taking it on an empty stomach helps it work faster
Tadalafil:
Usually begins working within 30-45 minutes
Can take up to 2 hours to reach full effect
Food does not significantly delay its onset of action
If you are looking for the absolute fastest option, Sildenafil might have a slight edge when taken on an empty stomach. However, the difference is not dramatic and both medications require some time to take effect.
Sildenafil vs Tadalafil: Which One is Right for You
Choosing between Tadalafil vs Sildenafil depends on several factors:
Prefer spontaneous sexual activity without planning.
Sexually active multiple times per week.
Want the option of daily dosing for continuous coverage
Find the idea of not having to plan medication before intimacy appealing.
The extended duration is one of the main Tadalafil benefits for many men, as it removes the need to time medication precisely before sexual activity. Men in long-term relationships often prefer Tadalafil because it allows for more natural intimacy without the "clock watching" that can come with shorter-acting options. Consider Sildenafil if:
You plan sexual activity in advance
You want a medication that clears your system more quickly
You have less frequent sexual activity (once a week or less)
You prefer taking medication only when needed
You are concerned about cost (generic Sildenafil is typically less expensive)
The predictable window of effectiveness with Sildenafil gives some men a sense of control. They know exactly when the medication is working and when it will stop, which can be reassuring for those who do not want medication active in their system for extended periods.
Both Sildenafil and Tadalafil are available in various brands and formulations globally. Here is a breakdown of some common options:
Medication | Brand Names | Available Strengths |
Sildenafil | Viagra, Revatio, Suhagra, Kamagra, Cenforce, etc. | 25 mg, 50 mg, 100 mg, (20 mg for PAH) |
Tadalafil | Cialis, Adcirca, Vidalista, Tadacip, etc. | 2.5 mg, 5 mg, 10 mg, 20 mg, (40 mg for PAH) |
Whether you choose Tadalafil or Sildenafil, following the proper dosage ensures you get the maximum benefit safely.
Final Thoughts
Tadalafil and Sildenafil have helped millions of men worldwide overcome erectile dysfunction and enjoy healthier intimate relationships. The best medication is the one that works effectively for you, has minimal side effects, and fits seamlessly into your lifestyle.
When comparing Tadalafil vs Sildenafil, remember that effectiveness varies from person to person. Some men respond better to one medication than the other. If the first medication you try does not work well, doctors often suggest trying the alternative.
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Disclaimer: The information provided by IndogenMed is for general informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting any medication.
Frequently Asked Question
Which is better, Sildenafil or Tadalafil?
Neither is universally "better" - they work similarly but have different durations and timing. Sildenafil works for 4-6 hours, while Tadalafil works for up to 36 hours. The best choice depends on how your body responds to each medication.
Is Tadalafil more expensive than Sildenafil?
Brand-name Cialis (Tadalafil) is typically more expensive than brand-name Viagra (Sildenafil). Generic versions of both are available and less expensive, but generic Tadalafil still tends to cost more than generic Sildenafil.
Which is better for daily use, Sildenafil or Tadalafil?
Tadalafil is approved for daily use in low doses (2.5mg or 5mg), whereas Sildenafil is not typically prescribed for daily use. If you prefer a daily regimen to stay ready for sexual activity at any time, Tadalafil may be the better option.
What are the common side effects of Sildenafil and Tadalafil?
Common side effects for both include flushing, headache, nasal congestion, indigestion, and back pain. Sildenafil more commonly causes visual disturbances (blue tinge to vision), while Tadalafil might cause limb pain more frequently.
How do Sildenafil and Tadalafil affect blood pressure?
Both medications can lower blood pressure slightly, which is usually not a problem for most men. However, they can cause a dangerous drop in blood pressure when combined with nitrates or alpha-blockers. Always discuss your complete medical history with your doctor before starting either medication.
Is one better for certain age groups than the other?
There is no clear age-related preference for either medication. However, older men (over 65) may be started on lower doses of either medication, as they might be more sensitive to side effects.
Can I get Sildenafil or Tadalafil over the counter?
In most countries, both medications require a prescription. In the UK, Sildenafil is available over the counter as Viagra Connect, but Tadalafil still requires a prescription. Always consult with a healthcare provider before taking these medications, even if you can access them without a prescription in your country.
How do I know which one is right for me, Sildenafil or Tadalafil?
The best way to determine which medication is right for you is to discuss your lifestyle and medical history with your healthcare provider. Some men find that one medication works better for them than the other, or that they experience fewer side effects with one versus the other. Your doctor might recommend trying both to see which works best for you.
Are there any long-term effects of using Sildenafil or Tadalafil?
Both medications have been studied extensively and are generally considered safe for long-term use when prescribed appropriately. However, it is important to address the underlying causes of ED when possible, rather than relying solely on medication.
Does Tadalafil help with BPH (enlarged prostate) as well as ED?
Yes, Tadalafil is FDA-approved to treat both erectile dysfunction and symptoms of benign prostatic hyperplasia (BPH), such as difficulty urinating. Sildenafil does not have this additional approval.
Reference:
https://www.webmd.com/drugs/2/drug-7418/Sildenafil-oral/details
https://www.webmd.com/drugs/2/drug-7418/Sildenafil-oral/details
https://pubmed.ncbi.nlm.nih.gov/19817982/
https://www.mayoclinic.org/drugs-supplements/Sildenafil-oral-route/description/drg-20066989
https://my.clevelandclinic.org/health/drugs/19136-Tadalafil-tablets-erectile-dysfunction-bph
https://www.mayoclinic.org/drugs-supplements/Tadalafil-oral-route/description/drg-20067204
https://www.webmd.com/drugs/2/drug-77875/Tadalafil-oral/details
