Zocon DT 100 Mg Tablets

Description

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Zocon DT 100 Mg Tablets

Zocon DT 100 Mg Tablets contain fluconazole 100 mg in a dispersible tablet formulation. Fluconazole is a broad-spectrum triazole antifungal medicine used to treat and prevent a wide range of fungal infections caused by Candida and Cryptococcus species. The dispersible (DT) formulation makes it easy to swallow, particularly useful for elderly patients or those who have difficulty swallowing conventional tablets.

Composition

About the Manufacturer

Zocon is manufactured by FDC Limited, an established Indian pharmaceutical company with expertise in antifungal and anti-infective preparations. FDC supplies to domestic and international markets and is known for quality formulations in its therapeutic focus areas.

Mechanism of Action

Fluconazole inhibits the fungal cytochrome P450 enzyme 14α-lanosterol demethylase, which is essential for the biosynthesis of ergosterol – a critical component of fungal cell membranes. Without ergosterol, fungal cell membrane integrity is compromised, leading to cell death. Fluconazole is fungistatic against most Candida species and fungicidal against Cryptococcus neoformans at achievable concentrations.

Indications

• Oropharyngeal and oesophageal candidiasis
• Vaginal candidiasis (thrush)
• Systemic Candida infections (candidaemia, peritoneal candidiasis)
• Cryptococcal meningitis (treatment and relapse prevention)
• Prophylaxis of fungal infections in immunocompromised patients (e.g. HIV, haematological malignancy, transplant recipients)
• Pityriasis versicolor (tinea versicolor)
• Dermatophyte infections (tinea pedis, tinea corporis)

Dosage & Administration

• Disperse the tablet in a glass of water and drink immediately
• Oropharyngeal candidiasis: 50–100 mg once daily for 7–14 days
• Vaginal candidiasis: 150 mg as a single dose
• Systemic candidiasis: 400 mg on day 1, then 200 mg daily
• Cryptococcal meningitis: 400 mg on day 1, then 200–400 mg daily for 6–8 weeks minimum
• Prophylaxis (immunocompromised): 50–400 mg once daily based on risk
• Can be taken with or without food

Special Populations

• Renal impairment (CrCl <50 mL/min): Use half the normal dose; for single-dose regimens, no adjustment needed
• Hepatic impairment: Use with caution in severe disease; hepatotoxicity is rare but monitor liver function
• Children: Weight-adjusted dosing under specialist supervision
• Pregnancy: High-dose fluconazole is associated with foetal abnormalities; avoid in first trimester; single doses for vaginal candidiasis are generally considered low risk but discuss with doctor
• Elderly: Standard doses; monitor renal function

Precautions

• Fluconazole can prolong the QT interval; avoid in patients with pre-existing QT prolongation or on other QT-prolonging drugs
• Monitor liver function tests in patients receiving repeated courses or long-term therapy
• Use with caution in patients with potential proarrhythmic conditions
• Rash may develop; discontinue if severe or if signs of Stevens-Johnson syndrome appear

Contraindications

• Hypersensitivity to fluconazole, other azole antifungals, or any excipient
• Concomitant use with terfenadine (at multiple fluconazole doses ≥400 mg/day), astemizole, cisapride, or quinidine
• High-dose fluconazole during pregnancy (teratogenic potential at ≥150 mg repeated doses)

Side Effects

• Common: Nausea, abdominal pain, diarrhoea, headache, skin rash
• Less common: Vomiting, elevated liver enzymes, dizziness, taste disturbance
• Rare: Hepatotoxicity (including liver failure), Stevens-Johnson syndrome, QT prolongation, anaphylaxis, alopecia

Drug Interactions

• Warfarin: Significantly increases anticoagulant effect; monitor INR closely
• Ciclosporin and tacrolimus: Increases blood levels; monitor drug levels and signs of toxicity
• Sulfonylureas (glibenclamide, glipizide): Enhanced hypoglycaemic effect; monitor blood glucose
• Phenytoin: Increases phenytoin levels; monitor and adjust dose
• Rifampicin: Reduces fluconazole levels; dose increase may be needed
• QT-prolonging agents: Additive risk; avoid combination

Storage

Store below 30°C in a dry place, protected from light. Keep out of the reach of children. Do not use after the expiry date printed on the packaging.

Related Products

• Amphotret 50 Mg Injection – amphotericin B for severe fungal infections
• Sebifin 1% W/W 10 Gm Cream – topical terbinafine antifungal cream
• Erytop 1% 20 Gm Gel – topical antibacterial for skin infections

Frequently Asked Questions

What is Zocon DT 100 Mg used for?

Zocon DT 100 Mg is used to treat fungal infections including oral, oesophageal, and vaginal thrush (candidiasis), skin fungal infections, and cryptococcal meningitis in immunocompromised patients.

What does DT mean in Zocon DT?

DT stands for Dispersible Tablet. It is designed to be dissolved in water before drinking, making it easier to swallow for patients who have difficulty with standard tablets.

How quickly does fluconazole work?

Many patients notice improvement in symptoms within 24–48 hours of taking fluconazole. However, the full course should always be completed as prescribed.

Can I take Zocon DT if I am on warfarin?

Fluconazole significantly increases the anticoagulant effect of warfarin. If you are on warfarin, your INR must be monitored closely, and your warfarin dose may need adjustment. Always inform your doctor.

Is a single dose enough for vaginal thrush?

For uncomplicated vaginal candidiasis, a single 150 mg oral dose of fluconazole is usually effective. For recurrent or complicated thrush, a longer course may be prescribed by your doctor.

References

1. NHS – Fluconazole
2. MedlinePlus – Fluconazole
3. FDA – Fluconazole Prescribing Information
4. EMA – Fluconazole-containing Medicines

Disclaimer: This page is for informational purposes only and does not constitute medical advice. Zocon DT 100 Mg Tablets should be taken as directed by your doctor. If you experience a serious rash, yellowing of the skin or eyes, or irregular heartbeat, seek immediate medical attention.

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