Truvada (emtricitabine / tenofovir disoproxil) Tablets - PrEP

Truvada is a prescription medication that combines two antiretroviral drugs: emtricitabine (200 mg) and tenofovir disoproxil fumarate (300 mg). Manufactured by Gilead Sciences, Truvada serves two main purposes. It helps prevent HIV infection in people who are at high risk, a strategy known as pre-exposure prophylaxis (PrEP), and it treats HIV infection when used with other HIV medications.

Truvada as PrEP has become a game-changer in HIV prevention efforts. When taken daily, it significantly reduces the risk of getting HIV from sex or injection drug use. For those already living with HIV, Truvada pills work alongside other antiretroviral medications to control the virus and prevent its spread within the body.

Key Benefits of Truvada 

Truvada offers several important benefits for users:

• Highly effective at preventing HIV infection when taken as directed

• Helps reduce anxiety about HIV for those at higher risk

• Can be part of a comprehensive HIV treatment plan

• Daily dosing makes it easier to fit into your routine

• Available as non-branded tablets at a lower cost

• Does not interfere with hormonal birth control methods

• Can be used by both men and women

How Truvada Works?

Truvada drug works in a straightforward but powerful way. The two active ingredients in Truvada, emtricitabine and tenofovir disoproxil fumarate are both nucleoside reverse transcriptase inhibitors (NRTIs). When HIV enters the body, it uses an enzyme called reverse transcriptase to multiply and spread. The medications block this enzyme.

For HIV prevention (as PrEP Truvada), the medicine builds up in your bloodstream and in the tissues that might be exposed to HIV during sex. If you are exposed to the virus, Truvada can stop it from establishing a permanent infection in your body. It is like having a shield that helps protect you from infection.

For HIV treatment, Truvada works with other antiretroviral drugs to lower the amount of HIV in the blood (viral load). This helps the immune system recover and reduces the chance of developing AIDS-related illnesses.

Dosage & Administration of Truvada 

Taking Truvada correctly is crucial for it to work effectively. Here is what you need to know about this medication:

1. Recommended Dosage

For adults and adolescents:

• Treatment of HIV-1: The typical dose is one Truvada pill (200 mg emtricitabine/300 mg tenofovir disoproxil fumarate) taken once daily along with other antiretroviral medications.

• Pre-exposure Prophylaxis (PrEP): For those at high risk of HIV infection, the same one-tablet daily dose is recommended. This use is often called Truvada prep or prep Truvada.

2. How to Take Truvada?

• With or Without Food: Truvada can be taken with food or on an empty stomach. Taking it with food may help reduce any mild stomach discomfort.

• Consistent Timing: Try to take your tablet at the same time every day to maintain even levels of medication in your bloodstream.

• Missed Dose: If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double up on tablets.

• Special Instructions: For those with kidney issues, your doctor may adjust the frequency or dose. Always follow your healthcare provider’s advice regarding dosage adjustments.

3. Administration Tips

• Storage: Store Truvada at room temperature in its original container, away from moisture and heat.

• Child Use: For pediatric patients, lower-strength tablets are available. Doses are adjusted according to body weight.

Strengths & Substitutes

Truvada comes in a single strength containing emtricitabine 200 mg and tenofovir disoproxil fumarate 300 mg. Here are some alternatives to this tablet:

Alternative Medications

In some cases, your doctor might suggest an alternative to Truvada. Some common alternatives include:

• Descovy: Another HIV medication used for both treatment and PrEP, containing emtricitabine and tenofovir alafenamide. It is sometimes preferred for its potentially milder impact on kidneys and bones.

• Dovato: It is a combination of dolutegravir and lamivudine, used in treatment regimens for HIV.

• Biktarvy: A complete regimen in a single tablet that combines three antiretroviral medications for treating HIV infection. It simplifies HIV treatment by offering a comprehensive solution in one pill.

When discussing these options, you might come across terms like “generic Truvada”, but there’s no such thing. What people mean by this term is the non-branded emtricitabine and tenofovir disoproxil fumarate tablets. 

Side Effects of Truvada 

Truvada doesn’t have serious side effects on most people, but like all medications, it can cause some. These usually improve within the first few weeks of taking the medication. Knowing the potential side effects can help you make informed decisions:

• Nausea

• Headache

• Stomach discomfort or diarrhoea

• Fatigue

• Dizziness

Some users may experience more serious side effects. If you experience any of the following, contact your doctor immediately:

• Kidney Problems: Signs include swelling, decreased urine output, or persistent tiredness. Regular kidney function tests are recommended.

• Bone Issues: Truvada has been linked with bone density loss in some patients. Report any unusual bone or joint pain.

• Liver Problems: Symptoms like yellowing of the skin or eyes (jaundice), dark urine, or severe abdominal pain.

• Lactic Acidosis: A rare but serious condition characterized by muscle pain, difficulty breathing, and confusion.

• Severe Allergic Reactions: Such as swelling of the face, lips, tongue, or throat, which require immediate medical attention.

If you are taking Truvada, your healthcare provider will monitor your kidney function through regular blood tests to catch any issues early. It is very important to discuss any side effects with your healthcare provider, as they can help manage or adjust your treatment plan. 

Who Should Use Truvada?

Truvada is for adults and adolescents who are HIV-positive or at high risk of contracting HIV. Consider these precautions:

• For Treatment: Only use as part of a complete antiretroviral regimen if you are HIV-positive.

• For Prevention (PrEP): Only take Truvada if you have tested HIV-negative. Regular testing is critical since starting Truvada PrEp in someone with undetected HIV can lead to drug resistance.

Important Safety Considerations for Truvada

Following are some of the most essential safety considerations you must take before consuming Truvada: 

1. Kidney Health: If you have a history of kidney problems, inform your doctor. Your kidney function will be monitored closely, and adjustments will be made.

2. Bone Health: Those with osteoporosis or other bone issues should be monitored since Truvada may lower bone mineral density.

3. Hepatitis B: Truvada is not approved for treating chronic hepatitis B. If you have hepatitis B, consuming Truvada suddenly can have serious side effects.

4. Medication Interactions: Inform your healthcare provider of all medications, supplements, and herbal products you are taking to avoid any harmful interactions.

5. Pregnancy and Breastfeeding: Pregnant or breastfeeding women should discuss the benefits and risks with their healthcare provider.

6. Adherence: The effectiveness of Truvada depends on taking the medication consistently. Missing doses can reduce its efficacy and increase the risk of HIV infection or treatment failure.

Things to Keep in Mind When Consuming Truvada

Here are all the things you should keep in mind when consuming Truvada:

• Truvada does not protect against other sexually transmitted infections (STIs), so using condoms is still recommended.

• Regular HIV testing is necessary when using Truvada for PrEP.

• Truvada should not be used to reduce HIV risk if you already have HIV or do not know your HIV status.

• Women who are pregnant or planning to become pregnant should discuss the risks and benefits with their healthcare provider.

Ready to take charge of your health? Visit Indogenmed today and explore our wide range of affordable, quality medicines designed to make a real difference in your life. Whether you’re looking for PrEP, HIV, oncology, or other essential therapies, our trusted, globally recognized pharmacy is here to serve you. 
Disclaimer: This information about Truvada is for educational purposes only and should not replace professional medical advice. Always consult a healthcare provider before starting any new medication. 

Reference: 

https://www.medicalnewstoday.com/articles/325820#What-is-Truvada 

https://www.healthline.com/health/drugs/truvada 

https://www.aidsmap.com/about-hiv/tenofovir-disoproxil-emtricitabine-prep 

https://www.webmd.com/drugs/2/drug-91482/truvada-oral/details 

https://www.medicalnewstoday.com/articles/325820 

https://www.gilead.com/-/media/736839e6330640e58f0d73f518c9abaf.ashx 

https://www.hiv.gov/hiv-basics/hiv-prevention/using-hiv-medication-to-reduce-risk/pre-exposure-prophylaxis