AVAILABLE MEDICINE FOR Atazanavir,emtricitabine,ritonavir,tenofovir Disoproxil Fumarate


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Introduction to Atazanavir, emtricitabine, ritonavir, tenofovir Disoproxil Fumarate

This is a combination antiretroviral therapy used to treat HIV-1 infection. Atazanavir is a protease inhibitor, Emtricitabine and Tenofovir are nucleoside reverse transcriptase inhibitors (NRTIs), and Ritonavir acts as a boosting agent.


How it Works:

  • Atazanavir: Blocks the HIV protease enzyme, preventing the virus from maturing and multiplying.
  • Emtricitabine and Tenofovir: These work by inhibiting reverse transcriptase, an enzyme HIV needs to replicate its genetic material.
  • Ritonavir: Enhances the effect of Atazanavir by inhibiting its metabolism, ensuring higher drug levels.


Uses:

  • Treatment of HIV-1 infection in adults and pediatric patients.
  • Part of combination therapy for antiretroviral treatment-naïve or experienced patients.

 

Side Effects: Common side effects include:

  • Nausea, diarrhea, and vomiting.
  • Jaundice (yellowing of the skin or eyes) from Atazanavir.
  • Kidney issues (from Tenofovir) or liver complications.


FDA Approval:

Atazanavir was first approved by the FDA in 2003, and Emtricitabine and Tenofovir have been part of several combination therapies approved in the following years.