AVAILABLE MEDICINE FOR Estramustine
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Introduction to Estramustine
Estramustine is an antineoplastic agent indicated in the palliative treatment of patients with metastatic and progressive carcinoma of the prostate. Estramustine is a combination of estradiol with nitrogen mustard. This causes DNA damage in rapidly dividing cancerous cells leading to cell death and ideally, tumor shrinkage. Estramustine medication belongs to the class of medications called microtubule agents. FDA initially approved the medicine on 24, December 1981 for the use of prostate cancer.
How Estramustine works
Estramustine is a derivative of estradiol with a nitrogen mustard moiety. This gives it alkylating properties. In vivo, the nitrogen mustard component is active and can alklyate DNA and other cellular components of fastly dividing cells. This causes DNA breaks or misscoding events. This leads to apoptosis and cell death. Also, due to the drug's estrogen component, it can bind more selectively to active estrogen receptors.
Uses of Estramustine
Estramustine is used to treat prostate cancer that has spread to other parts of the body.
