AVAILABLE MEDICINE FOR Darunavir, ritonavir
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introduction to Darunavir, ritonavir
Darunavir, in combination with ritonavir, was approved by the U.S. FDA on June 23, 2006, for the treatment of HIV-1 infection. Darunavir is a protease inhibitor, while ritonavir is used as a pharmacokinetic enhancer to boost the levels of darunavir in the blood.
How Darunavir and Ritonavir Work
Darunavir works by inhibiting the action of the HIV-1 protease enzyme, which is essential for the maturation of the virus. By preventing this enzyme from functioning, the medication stops the virus from replicating effectively. Ritonavir, although also a protease inhibitor, is used in this combination primarily to increase the effectiveness of darunavir by slowing its metabolism, thereby maintaining higher plasma concentrations.
Uses of Darunavir and Ritonavir
This combination is commonly used to treat:
- HIV-1 infection in adults and children aged 3 years and older
- Multidrug-resistant HIV-1 strains
Warnings
- Do not use darunavir and ritonavir if you are allergic to either drug or any of their ingredients. Avoid taking this combination if you have:
- Severe liver disease
- Known hypersensitivity to sulfonamides (due to potential cross-reactivity with darunavir
Precautions
Before starting darunavir and ritonavir, inform your doctor if you
- Have liver or kidney disease
- Are taking other medications that may interact with this combination
- Are pregnant or breastfeeding
- Regular monitoring of liver function tests and viral load is recommended during treatment.
Side Effects
Common side effects include:
- Diarrhea
- Nausea
- Rash
- Headache
- Increased liver enzymes
- Hyperlipidemia
Serious side effects may include severe allergic reactions, liver toxicity, and the development of immune reconstitution syndrome.
Advice
- If you have underlying liver conditions or other significant health issues, use this combination carefully and under strict medical supervision. Do not stop taking the medication unless advised by your doctor, and do not double up on doses if a dose is missed
- If you are pregnant or breastfeeding, consult your healthcare provider before starting or continuing this medication. Report any severe side effects to your doctor immediately, as dose adjustments may be necessary.
- Store this medication in a cool, dry place away from children and pets, and check the expiration date before use.
