AVAILABLE MEDICINE FOR Regorafenib

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introduction to Regorafenib

Regorafenib was approved by the U.S. FDA on September 27, 2012, for the treatment of metastatic colorectal cancer, gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma. It is a kinase inhibitor that works by blocking several enzymes involved in the growth of cancer cells.

How Regorafenib Works

Regorafenib inhibits multiple protein kinases that play a role in tumor angiogenesis, oncogenesis, and the tumor microenvironment. By blocking these kinases, it reduces tumor growth and prevents the spread of cancer cells.

Uses of Regorafenib

Regorafenib is used to treat:

Metastatic colorectal cancer
Gastrointestinal stromal tumors (GIST) after progression on other therapies
Hepatocellular carcinoma after progression on sorafenib

Warnings

Do not use regorafenib if you are allergic to it or any of its ingredients. Avoid using it if you have:
Severe liver impairment
A history of cardiac arrhythmias or ischemic heart disease

Precautions

Before starting regorafenib, inform your doctor if you:

Have a history of liver disease, heart conditions, or bleeding disorders
Are taking any other medications, especially blood thinners or anti-inflammatory drugs
Are pregnant or planning to become pregnant
Your doctor may monitor liver function and other vital signs regularly during treatment.

Side Effects

Common side effects include:

Fatigue
Hand-foot syndrome
Diarrhea
High blood pressure
Liver enzyme elevation
Serious side effects may include liver failure, severe bleeding, cardiac issues, and gastrointestinal perforation.

Advise

Use regorafenib cautiously if you have pre-existing liver or heart conditions. Do not stop taking the medication without consulting your doctor, and do not take an extra dose if you miss one.
If you are pregnant or breastfeeding, discuss with your healthcare provider before starting or continuing regorafenib. Report any serious side effects to your doctor immediately for possible dose adjustment.
Store regorafenib in its original container at room temperature, away from moisture, and keep it out of reach of children and pets.